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Drug Development

ERK protein activation assists in adipocyte maturation and regulation of lipid blood level

According to recent research from Japan, "Natural products with distinct biological activities are very promising molecular probes to dissect the novel pathways of biology. FR177391, a product of bacteria, was obtained as a natural compound possessing anti-hyperlipidemic effects."

M. Yamaoka and colleagues working at Fujisawa Pharmaceutical wrote, "FR177391 enhances differentiation of mouse 3T3-L1 fibroblasts to adipocytes and reduces the circulating levels of triglyceride in C57BL/KsJ-db/db mice, a obese non-insulin-dependent diabetes mellitus animal...

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