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Drug Resistance
Cyclooxygenase-1 haplotype modulates platelet response to aspirin
December 29th, 2005
Genetic variability in cyclooxygenase-1 appears to modulate platelet response to aspirin. "Aspirin (acetylsalicylic acid) irreversibly inhibits platelet cyclooxygenase (COX)-1, the enzyme that converts arachidonic acid (AA) to the potent platelet agonist thromboxane (TX) A2 . Despite clear benefit from aspirin in patients with cardiovascular disease (CAD), evidence of heterogeneity in the way individuals respond has given rise to the concept of 'aspirin resistance,'" investigators at Harvard University report. Their study was conducted "to evaluate the hypothesis that incomplete suppression of platelet COX as a consequence of variation in the COX-1 gene may...
Source: Blood Weekly (2005-12-29)
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