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Hypertension
High lipophilicity linked to improved performance in angiotensin II receptor blockers
December 29th, 2005
High lipophilicity has been linked to improved performance in antihypertension drugs that target the angiotensin II receptor. "Although the lipophilicities of the various angiotensin II receptor blockers (ARBs) are very different, the relationship between lipophilicity and the protective effect against vascular remodeling is unclear," scientists in Japan explained. In a recent study, S. Takei and coauthors at Osaka Medical College "compared the protective effects of a highly lipophilic ARB, telmisartan, and an ARB with low lipophilicity, losartan, on vascular function and oxidative stress in stroke-prone spontaneously hypertensive rats...
Source: Blood Weekly (2005-12-29)
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