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Hypoxia
Tumor hypoxia alters macrophage migration and gene expression
December 29th, 2005
According to research from England, tumor hypoxia alters macrophage migration and gene expression. "Monocytes are recruited into tumors from the circulation along defined chemotactic gradients and they then differentiate into tumor-associated macrophages (TAMs)." "Recent evidence has shown that large numbers of TAMs are attracted to and retained in avascular and necrotic areas, where they are exposed to tumor hypoxia," wrote C. Murdoch and colleagues, University of Sheffield. "At these sites, TAMs appear to undergo marked phenotypic changes with activation of hypoxia-inducible transcription factors, dramatically upregulating the...
Source: Blood Weekly (2005-12-29)
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