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Immunology
Immunostimulation alone is insufficient to enhance antiviral T-cell reactivity
December 29th, 2005
Researchers in England reported that immunostimulation alone is insufficient to enhance anti-hepatitis C virus (HCV) T-cell reactivity. "To gain understanding of inter-individual differences of treatment response in HCV genotype 1 (HCV-G1) patients, we investigated simultaneously the early HCV kinetics and virus-specific T-cell reactivity," wrote K.H. Tang and colleagues, University College London. "Thirty treatment-naive HCV-G1 patients received peginterferon-alfa2a (180 mcg/week) plus ribavirin (10,001,200 mg/day), with blood samples collected prospectively at protocol time-points. HCV RNA was quantitated with a TaqMan assay with mathematical...
Source: Blood Weekly (2005-12-29)
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