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Leukemia
Cyclophosphamide and fludarabine used to treat chronic lymphocytic leukemia
December 29th, 2005
Cyclophosphamide and fludarabine could be used to treat chronic lymphocytic leukemia (CLL). "B-cell CLL accounts for 95% of chronic leukemia cases and 25% of all leukemia. Despite the prevalence of CLL, progress in its treatment has been only modest over the past 3 decades," scientists in the United States reported. "Based upon the ability of fludarabine to produce high-grade remissions especially among patients with low initial tumor mass, and the ability of alkylators to reduce tumor mass, we hypothesized that sequential administration of a limited number of cycles of intermediate-dose cyclophosphamide followed by fludarabine could result in a...
Source: Blood Weekly (2005-12-29)
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