Adverse Drug Reaction
Papillomavirus-associated squamous cell carcinoma developed in dog after chronic cyclosporine
Published in Blood Weekly, January 5th, 2006
"A 4-year-old, spayed female toy fox terrier developed multiple epidermal hamartomas and squamous cell carcinomas in situ following chronic immunosuppressive therapy with prednisone and cyclosporine for management of an immune-mediated nonregenerative anemia.
"Immunohistochemical staining was positive for papillomavirus antigen within both benign (n=19) and malignant (n=8) cutaneous lesions that developed during a 3-year period of observation, with positive staining most often seen in keratinocytes in the granular cell...
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Source: Blood Weekly (2006-01-05)
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