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Blood Weekly

Susan Hasty, Publisher

Table of Contents . . . January 12th, 2006

Non-Subscriber - Summaries Only

Related Areas: Other Issues in Blood Weekly | Other Publications

Cord Blood - Unrelated cord blood transplant successful in children with Shwachman-Diamond syndrome

Liver Regeneration - Partial hepatectomy induces mobilization of stem cells in healthy liver donors

Stem Cell Research - Antibody-conjugated magnetoliposomes rapidly and efficiently expand mesenchymal stem cells

Tissue Engineering - Keratinocytes and dermal fibroblasts cultured on PLGA microspheres regenerates skin

Tissue Engineering - Pulsed low intensity ultrasound stimulates intervertebral disc cell cellular metabolism

Acute Lymphoblastic Leukemia - European study confirms efficacy of clofarabine in pediatric patients with ALL

Acute Myeloid Leukemia - Acute myeloid leukemia blasts regularly express PRR1 and PRR2

Adenovirus - Nonhuman adenovirus alters human memory T cells

Angiology - Early post-op coagulation and fibrinolysis are linked to myocardial damage

Apoptosis - Doxorubicin induces apoptosis in germ line stem cells in the immature testis

Biomaterials - Silk implants form trabecular-like bone matrices in bioreactors

Blood-Borne Pathogens - Perisinusoidal B cells in BM participate in T-independent response to blood-borne microbes

Breast Cancer - Oxidative stress implicated in breast cancer

Business & Finance - Biologics maker announces filing of application to appoint receiver and resignation of directors

Business Update - Vasovist maker to reduce workforce

Cancer Diagnostics - Methods for enumerating circulating tumor cells in carcinoma patients compared

Cancer Therapy - Hematologic safety and tolerability of topotecan investigated

Cancer Therapy - Human acute lymphoblastic leukemia cells produce human pregnancy hormone hCG

Cancer Therapy - Positive PXD101 phase I results presented at the American Society of Hematology

Cancer Therapy - Quadramet/ bortezomib combo demonstrates broad anticancer activity in preclinical study

Cancer Vaccines - New data illuminates research in Cancer Vaccines

Cardiac Papillary Fibroelastoma - Surgery used to treat cardiac papillary fibroelastoma

Cardiology - New findings in the area of cardiology described

Chronic Lymphocytic Leukemia - Drug for lymphocytic leukemia shown to be generally well tolerated and biologically active

Colon Cancer - Anemia deemed poor predictor of right-sided colon cancers

Colorectal Cancer - DCs fused with colorectal cancer cells induce immunity against autologous tumor cells

Cord Blood - UCBT cures severe chronic active Epstein-Barr virus infection after double HSCT failure

Diabetes Pathogenesis - Renal cortex of streptozotocin-induced diabetic rats has lower nitric oxide levels

Diagnostics - Diagnostics company presents data on soon-to-be introduced assay for hematologic diseases

Diagnostics - Laparoscopic-guided liver biopsy safe and informative in pediatric HSCT

Diagnostics - Molecular end point can be a safe and effective tool for clinical decision making

Diagnostics - Recent findings in diagnostics described

Diet & Nutrition - Vitamin D is important for prevention of bone, heart, and autoimmune diseases

Disease Associations - Family history of hematopoietic malignancy related to higher risk of lymphoma

Disease Associations - Greater awareness needed for adverse impact of anemia on cancer patients

Disease Associations - Risk factors leading to hypercholesterolemia and colorectal cancer studied

Drug Development - Proteasome inhibitors evaluated in lymphoid malignancies

Epistaxis - Arterial embolization is an effective treatment for severe epistaxis

Fanconi Anemia - Assay established for complement assignments in FA patients

Gene Expression - Factor VIIa binding causes differential gene expression in macrophages

HIV/AIDS HAART - HAART associated with life-threatening maternal and fetal macrocytic anemia

Healthcare Costs - Itraconazole more cost effective than amphotericin B for systemic fungal infections

Helicobacter pylori -  H. pylori eradication results in complete histological remission of MALT lymphoma

Hematology - Amifostine cuts vascular endothelial growth factor secretion in hemopoietic stem cells

Hematology - Studies suggest red blood cell transfusions may be unnecessary for all heart surgeries

Hemophilia - Study of Factor VIII demonstrates efficacy to prevent joint bleeding in hemophiliacs

Hemophilia Epidemiology - Report reviews demographics of hemophilia in developing countries

Hepatitis B Virus - Extraction of hepatitis B virus RNA and DNA automated for real-time PCR

Hepatitis B Virus - New data illuminates research in Hepatitis B Virus

Hepatitis C Virus - Chronic viral hepatitis influences graft survival in renal transplant patients

Hepatitis D Virus - Hepatitis D virus screening serological test required

Hodgkin Lymphoma - Epstein-Barr virus is prognostic marker of survival after Hodgkin lymphoma

Human T Cell Leukemia Virus - Mutations in determinants of HTLV-1 Env SU do not prevent viral replication

Imaging - PET imaging detects mesenchymal stem cell targeting of microscopic tumors

Information Technology - Blood Connection selects blood donor management system

Intracerebral Hemorrhage - Collaboration to codevelop recombinant factor VIIa therapeutics for acute bleeding

Intracerebral Hemorrhage - Rapid antifibrinolytic treatment with strict blood pressure control reduces hematoma growth risk

Ischemia - Chronic administration of ethyl docosahexaenoate decreases mortality, cerebral edema in ischemic gerbils

Leukemia - Cladribine used to treat hairy cell leukemia

Leukemia - Early allogeneic stem-cell transplantation used to treat leukemia

Leukemia - Preclinical studies of GX15-070 show it induces apoptosis in several types of blood cancers

Leukemia - Relation between breastfeeding and reduced risk of childhood leukemia needs further study

Lipid Research - Amphotericin B lipid complex effective in HCT recipients with invasive aspergillosis

Lipid Research - Effective LDL apheresis reduces RBC aggregation by altering plasma composition

Liver Regeneration - PFT induced p53 inhibition does not affect liver regeneration after partial hepatectomy

Lung Cancer - Radical lung resection advised for select, non-small cell lung cancer patients

Lung Cancer Prognostic Marker - Telomerase expression in noncancerous bronchial epithelia may be early lung cancer marker

Lymphocytic Leukemia - Lymphocytic leukemia study shows survival benefit of up to 31 months after MabCampath treatment

Lymphoma - Biologic agent may improve efficacy of rituximab in relapsed follicular lymphoma

Lymphoma - International Prognostic Index used to predict survival in non-Hodgkin lymphoma

Malaria Research - Study of merozoite surfaces provides insight into erythrocyte invasion, anti-parasite immunity

Malaria Therapy -  Plasmodium falciparum's separate organelle-specific pathways are both potential targets for drug development

Medical Devices - InDuo is as effective as HumaPen Ergo and Accu-Chek Sensor Meter for insulin and BG control

Multiple Myeloma - CD52 is not a promising target for antibody-based therapies for most patients with multiple myeloma

Multiple Myeloma - Resveratrol inhibits myeloma cell growth and promotes osteoclast differentiation

Myelodysplastic Syndrome - Encouraging data on Vidaza presented at American Society of Hematology meeting

Myelodysplastic Syndromes - WHO classification of myelodysplastic syndromes predicted prognosis and survival

Myelofibrosis - Revlimid trial shows 59% of evaluable patients with myelofibrosis responded to treatment

Neisseria Mucosa -  Neisseria mucosa peritonitis reported in adolescent patient

Neurogenesis - CREB protein regulates differentiation, survival of newborn neurons in the olfactory bulb

Neurogenesis - Chronic HU210 treatment produces anxiolytic- and antidepressant-like effects

Neuroscience - Data advance knowledge in neuroscience research

Obesity Complications - Increasing BMI is strongly related to the CHD risk factors systolic blood pressure and HDL

Oral Mucositis - Encouraging preliminary top-line phase II results reported on velafermin

Pediatric Cancer - Physical performance among long-term survivors of childhood cancer limited

Personnel - Biopharma company names Christian Frayssignes CEO of animal sciences

Personnel - Company focused on blood viscosity appoints Dan Cho to management team

Personnel - Patricia Ferrin Loucks named new head of consumer marketing for stem cell bank

Pulmonary Hypertension - Pulmonary hypertension may be a common condition in paroxysmal nocturnal hemoglobinuria

Quality of Life - Personal factors associated with global quality of life after stem cell transplantation

SARS - Researchers publish new studies and findings in the area of SARS

Sickle Cell Anemia - Research identifies new biomarker for pulmonary hypertension in sickle cell patients

Stem Cell Research - Balloon cells express neural stem cell surface marker CD133

Stem Cell Research - Deer antler regeneration may be stem cell based

Stem Cell Research - Experimental Alzheimer, diabetes drug appears to enhance therapeutic effect of cord-blood transplant

Stem Cell Research - FGF directly required in epiblast cells for spine stem zone specification and maintenance

Stem Cell Research - FITC-conjugated mesoporous silica nanoparticles efficiently internalized into MSCs

Stem Cell Research - MRI detects brain tissues likely to undergo angiogenesis after cell therapy

Stem Cell Research - Mesenchymal stem cells transplanted to degenerative discs proliferate and differentiate

Stem Cell Research - Mice are important to the study of stem cell biology

Stem Cell Research - NSCs and MSCs interaction are important for generation of neural-like cells

Stem Cell Research - Neural stem cells isolated from damaged cerebral cortex after traumatic brain injury

Stem Cell Research - Nucleostemin is expressed in BMSCs and turns off after induction of neural differentiation

Stem Cell Research - Perfusion cultures improve cell densities of embryonic stem cells

Stem Cell Research - Research studies confirm promise of novel cord blood stem cell from biomedical company

Stem Cell Research - Selection against methylation loss may provide the basis for X-chromosome instability

Stem Cell Transplantation - Adult bone marrow-derived stem cells may be key to myocardial repair

Stem Cell Transplantation - BM stromal cell treatment provides long-lasting benefit after brain injury

Stem Cell Transplantation - Extramedullary leukemic relapse after HSCT associated with a poor prognosis

Stem Cell Transplantation - G-CSF analogs eradicate NKT cell-dependent leukemia after stem cell mobilization

Stem Cell Transplantation - HHV6 variant B infection delays platelet engraftment after stem cell transplantation

Stem Cell Transplantation - Inherited prothrombotic abnormalities contribute to CVC-related thrombosis after HSCT

Stem Cell Transplantation - Integrin and extracellular matrix interactions regulate hepatocyte engraftment

Stem Cell Transplantation - PBSC remobilization ensures rapid and safe engraftment for poor mobilizers

Stem Cell Transplantation - Pretransplant factors associated with better survival in Philadelphia chromosome+ ALL

Stem Cell Transplantation - Transplanted mesenchymal stem cells regenerate intervertebral discs

Stem Cell Transplantation - Unrelated donor SCT significantly associated with increased CMV infection risk in children

Stroke - Insulin-like growth factor axis is involved in ischemic stroke pathogenesis

Surgical Technology - Precoagulation minimizes blood loss in pig model

Tissue Engineering - Adding bMSC sheets to PLLA scaffolds makes ligament analogs stronger, more stretchable

Tissue Engineering - Fetal liver cells differentiate in 3-dimensional perfusion culture system

Tissue Engineering - Mesenchymal stem cells have potential for a wide range of tissue engineering applications

Transplant Medicine - Ex vivo expanded DCs home to T-cell zones of lymphoid organs and survive in vivo after BMT

Transplant Medicine - New data illuminates research in Transplant Medicine

Type 1 Diabetes - Diabetics experience elevated plasma atrial and brain natriuretic peptide levels

Type 2 Diabetes - Pulse pressure predicts cardiovascular risk in patients with type 2 diabetes mellitus

Venous Thromboembolism - Study shows 300,000 Americans die each year from complications of deep-vein thrombosis

Wound Healing - Autologous bone marrow stem cells accelerate the repair of diabetic foot lesions

Wound Healing - DHEA accelerates cutaneous wound healing via estrogen receptors

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