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Acute Lymphoblastic Leukemia

European study confirms efficacy of clofarabine in pediatric patients with ALL

Published in Blood Weekly, January 12th, 2006

Bioenvision (BIVN) has provided preliminary data from the company's phase II sponsored study of clofarabine in pediatric patients with relapsed/refractory acute lymphoblastic leukemia (ALL).

The update was given to a meeting of study investigators and European and Japanese hematologists.

Bioenvision reported a total of 37 patients have been enrolled to date in study BIOV-111, which is being conducted in 40 European centers (11 U.K.; 11 France; 9 Germany; 6 the Netherlands; 2 Italy; 1 Austria). Of the 20 evaluable patients, 5 (25%) have achieved, according to investigator assessment, a complete response (CR + CRp). "This is similar to the 20% complete...

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