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Blood Weekly

Susan Hasty, Publisher

Table of Contents . . . January 19th, 2006

Non-Subscriber - Summaries Only

Related Areas: Other Issues in Blood Weekly | Other Publications

Blood Safety - Modified procedure safe and effective for collection of cytokine-mobilized PBCs

Chronic Myeloid Leukemia - Imatinib mesylate enhances chronic myeloid leukemia stem cell elimination

Tissue Engineering - Composite tissue-engineered intervertebral discs similar to native tissue

Tissue Engineering - Perfusion bioreactor system produces clinically relevant volumes of tissue-engineered bone

Tissue Engineering - Trachea reconstructed from tissue engineered human hyaline cartilage

Acute Coronary Syndromes - Platelet hyperfunction is suggested in acute coronary syndromes

Aging - Blood pressure influences increase with normal aging

Alcohol Abuse - Alcohol has greater behavior and physical stress effects in adolescent rats than in adult rats

Amylin - Amylin peptide levels are raised in infants of diabetic mothers

Angiology - Blood flow in skin of type 1 diabetic patients improved after pancreas transplant

Angiology - Precise surgical anatomy knowledge required to prevent iatrogenic vertebral artery injury

Cancer Therapy - Research in Cancer Therapy provides new insights

Breast Cancer - Beta integrins are inessential for murine mammary tumor growth and progression

Breast Cancer - Human embryonic SC genes OCT4/NANOG/STELLAR/GDF3 expressed in seminoma and breast cancer

Breast Cancer - Prediction model being developed to identify risk of developing anemia

Business Update - Biopharma company updates European commercialization strategy to reduce expenses

Cancer Risk Factors - Exposure to drinking-water nitrate as a cancer risk factor evaluated

Cancer Therapy - Findings advance knowledge in Cancer Therapy research

Stem Cell Transplantation - Studies add new findings to Stem Cell Transplantation body of knowledge

Cancer Therapy - Monophenolic compounds induce minimal apoptosis in murine leukemia cells

Cardiology - Glucose deviations in AMI patients without diabetes may be due to impaired beta cell function

Cardiology - Lowering BP and TG cutoff may predict coronary heart disease and diabetes risk

Cardiovascular Disease - Platelet polymorphisms may contribute to oral strep-induced thrombogenesis

Cardiovascular Disease Risk Factors - National Cholesterol Education Program may underestimate risk in asymptomatic subjects

Transplant Medicine - Researchers report details of new studies and findings in the area of Transplant Medicine

Cartilage Repair - Aged chondrocytes have diminished capacity to produce functional extracellular matrix

Cerebral Hematoma - High dose methylprednisolone reduced intracerebral hemorrhage after hematoma in animal model

Chronic Hemodialysis - Subclavian vein catheterization has high success rate, even in high-risk patients

Clinical Trials - Investigational protein shown to increase platelet production in ITP patients

Clinical Trials - Positive phase I/2 data of immunotherapy product in cutaneous lymphoma reported

Clinical Trials - Small molecule drug treatment demonstrates significant responses in phase II MDS trial

Clinical Trials - Velcade trial shows positive results in variety of lymphomas

Collagen Scaffolds - Photochemical crosslinking improves physicochemical properties of collagen scaffolds

Complementary & Alternative Medicine -  E. alatus prevents high-fat diet induced hyperglycemia and hyperlipidemia in mouse model

Complementary & Alternative Medicine - Nitobegiku showed antidiabetic properties in KK-Ay diabetic mice

Cord Blood - Congressional action enhances Center for Cord Blood capability

Cord Blood - U.S. president signs bill establishing national umbilical cord blood program

Coronary Artery Disease - Faulty CXCR4 signals impede the ability of endothelial progenitor cells to form new vessels

DNA Research - Chromatin domain activation utilizes dispersed GATA motifs

Diabetes Complications - Abnormal circulation with normal ABI is linked to atherosclerosis and artery stiffness

Diabetes Control - A dose of insulin glargine provided glycemic control as effective as NPH insulin

Diabetes Management - Phenomen study found management of risk factors in diabetic hypertensives inadequate

Diabetes Therapy - Simvastatin treatment reduced apoB-lipoprotein secretion in diabetic dyslipidemia

Diet & Nutrition - Vitamin C reduces inflammatory gene expression in smokers with apolipoprotein E4 activity

Diet & Nutrition - Weight loss did not improve flow-mediated dilatation

Disease Associations - Case of testicular tumor related to Down syndrome

Disease Associations - Daily bacteremia may be source of inflammatory markers

Disease Associations - EBV+ CNS lymphoma resolves with appearance of CSF EBV-specific T cells

Disease Associations - Fever of unknown origin associated with cancer

Drug Delivery - Temperature-responsive hydroxybutyl chitosan cultures MSCs and intervertebral disk cells

Drug Development - HIF-PH inhibitor increases hemoglobin levels in preclinical study of chronic anemia

Drug Development - Heparin octasaccharides block angiogenesis in cancer models without affecting coagulation

Drug Safety - Outpatient dalteparin therapy safe for patients with mechanical heart valves

Epilepsy - Topiramate reduces seizure frequency in patients with epilepsy and intellectual disability

Erythropoiesis - Hanging drop culture method allows study of terminal erythroid differentiation

Finance - Cell therapeutics technology company announces shelf registration declared effective

Fitness & Wellness - Antioxidant capacity of most subjects provides protection from short exercise challenges

Gastroenterology - Gut edema delays intestinal transit via an iNOS-mediated mechanism

Genetics & Genomics - Oct4 pseudogenes are transcribed in cancers

Genetics & Genomics - Pluripotency homeobox gene NANOG expressed in germ cell tumors

Health Policy - Central Blood Bank modifies donor identification policy

Hemangioendothelioma - Surgical treatment of primary hepatic epithelioid hemangioendothelioma described

Hemangioma - A sclerosing agent can be injected in hemangiomas to reduce size, pain, and to improve function

Hemangiomas - Current knowledge of pathogenesis of infantile hemangiomas discussed

Hepatitis B Treatment - Results from phase 2 Hepex-B study are positive

Hepatitis C Virus - HCV core protein inhibits promyelocytic leukemia function in hepatoma cells

Hepatitis C Virus - Simultaneous detection of HCV core antigen and antibody can replace nucleic acid testing

Hepatitis E Virus - An immunochromatographic assay is sensitive and specific for hepatitis E virus

Hodgkin Lymphoma - Clinicopathological features of Hodgkin lymphoma in Taiwan characterized

Hodgkin Lymphoma - High-dose therapy and AHSCT does not increase risk of second neoplasm in Hodgkin lymphoma

Hypertension - Blood pressure-dependent inhibition of renin secretion requires adenosine receptors

Hypertension - Ethnic differences are prevalent in hypertension rates among women

Hypertension - Intracranial pressure response to hypertension impairs autoregulation

Hypertension - Kinase polymorphism influences blood pressure response to a thiazide diuretic

Intracranial Aneurysms - Late rebleeding rare after treatment of rupture with detachable coils

Leukemia - ABL1 amplification in T-cell acute lymphoblastic leukemia studied

Leukemia - All-trans retinoic acid and anthracycline used to treat pediatric leukemia

Leukemia - Allogeneic transplant overcame poor prognosis of chronic lymphocytic leukemia

Leukemia - Fluorescence in situ hybridization detected cutaneous lesions

Leukemia - Four-color flow cytometry used to detect minimal residual disease in acute lymphoblastic leukemia

Leukemia - Immunoglobulin mutational status used as prognostic marker for clinical outcome

Leukemia - No increase in leukemia incidence found due to Chernobyl accident

Leukemia - Significance of RUNX1 rearrangements in acute lymphoblastic leukemia discussed

Medical Devices - Endovascular stent angioplasty is a safe, effective treatment for spontaneous coronary artery dissection

Medical Devices - Use of off-pump CPB reduces transient hepatocellular damage

Melatonin - Melatonin reduces reticuloendothelial blockade and improves iron status during inflammation

Mycobacterium Bovis BCG - Neutrophil stimulation with M. bovis BCG causes release of functional soluble TRAIL/Apo-2L

Nanotechnology - Nanoparticles cytotoxic to germline stem cells

Nephrology - Humoral alloreactivity requires ongoing analysis in kidney transplant recipients

Nerve Regeneration - Coil-reinforced hydrogel tubes promote nerve regeneration equivalent to nerve autografts

Neurogenesis - Cystatin C modulates neurodegeneration and neurogenesis following status epilepticus

Neurogenesis - Ghrelin stimulates neurogenesis in the nucleus of the solitary tract

Neurogenesis - Shp2-binding site disruption in FRS2 alpha leads cerebral cortex development impairment

Neurology - Selective uptake of agouti-related protein(82-131) may be modulated by food deprivation

Neuroscience - Damage within white matter underlies executive dysfunction in CADASIL

Obesity Therapy - (-)-HCA-SX reduced appetite and body weight, improved fat oxidation, and blood lipid levels

Obstetrics - Uterine lymphocytes may promote endometrial angiogenesis during pregnancy

Occupational Exposure - Cancer mortality among North American synthetic rubber industry workers studied

Oncology - "Lab card" whole blood rare cancer cell analyzer developed

Oncology - Myeloma cell gene regulation produces osteopontin and angiogenesis

Pancreatic Cancer - Blood test for pancreatic cancer has 77% sensitivity and 95% specificity

Pediatric Obesity-Related Hypertension - Adolescent obesity is linked to high ambulatory BP and increased carotid IMT

Peripheral Artery Disease - Extracorporeal blood oxygenation and ozonation treats PAD lesions

Peripheral Vascular Disease - Bone marrow cell therapy and metabolic intervention improve hindlimb ischemia in mice

Pregnancy - Hemoglobin levels are linked to age/smoking, but not ferritin levels, during pregnancy

Renal Transplantation - HBsAg positive transplant recipients are at increased risk for mortality and graft failure

SARS - Findings in SARS provide new insights

Sepsis - Melatonin may protect against mtNOS-mediated mitochondrial failure

Spinal Cord Regeneration - Matrix inclusion improves regenerated axon number in the damaged spinal cord

Spinal Cord Regeneration - Multiple-channel scaffolds promote spinal cord axon regeneration

Stem Cell Legislation - President Bush signs umbilical cord blood bill

Stem Cell Research - Bax limits adult neural stem cell persistence through caspase and IP3 receptor activation

Stem Cell Research - CD34+ cells are mobilized into peripheral blood during cardiac-related stress

Stem Cell Research - Cardiac SCs are restored after MI by self-proliferation and selective homing of BM-derived SCs

Stem Cell Research - Cellular/microenvironmental changes in culture can significantly affect HSC output

Stem Cell Research - Chelatable cellular copper modulates CB-derived CD34+ cell differentiation/self-renewal

Stem Cell Research - Ex vivo system promotes stem-like cell trafficking from ventricles to culture surface

Stem Cell Research - FDA lifts clinical hold on CB001 trial

Stem Cell Research - MSCs accumulate endothelial nitric oxide synthase in the nucleus without acute stimulus

Stem Cell Research - Mesenchymal stem cells repair conduction block

Stem Cell Research - Nanoscale topography modulates corneal epithelial cell migration

Stem Cell Research - Simple method labels stem cells with fluorine 18

Stem Cell Research - Some types of stem cells do not migrate towards brain tumors

Stem Cell Research - TLR and NOD2 ligands induce cell proliferation in the intact spinal cord

Stem Cell Transplantation - Findings advance knowledge in Stem Cell Transplantation research

Stem Cell Transplantation - Healthy SC donors have sufficient telomere length reserve to repopulate treated host

Stem Cell Transplantation - Quinolones may prevent hemorrhagic cystitis by suppressing BK virus after HSCT

Stem Cell Transplantation - Reduced-intensity conditioning preserves thymic function in early period after HSCT

Stem Cell Transplantation - X-linked adrenoleukodystrophy successfully treated with ASCT and fludarabine

Stroke - Growth factor augments bone marrow stromal cell transplantation after cerebral infarction in rats

Surgical Technology - Heparin-bonded circuits reduce RBC transfusion rates during elective CABG surgery

Thrombosis -  Bacillus subtilis natto protein has antithrombotic and fibrinolytic effects

Tissue Engineering - Atelocollagen collagen gel improves DNA synthesis and content of nucleus pulposus cells

Tissue Engineering - Crosslinked chitosan increases the mechanical strength of chitosan scaffolds

Tissue Engineering - DRG neuron subpopulation extends neurites across micropatterned grooves

Tissue Engineering - Endothelial cell sheets can be used to treat damaged corneas

Tissue Engineering - MSCs differentiate into bone and cartilaginous tissues in 3D collagen gel cultures

Tissue Engineering - Transplanted chondrocytes seeded on collagen-based scaffold repairs cartilage defects

Transplant Medicine - BK virus infection creates a microenvironment promoting graft fibrosis

Transplant Medicine - Cold ischemia, reperfusion injury, and graft CAD share linear link

Transplant Medicine - Extracardiac progenitor cells repopulate most major cell types in transplanted heart

Transplant Medicine - Multipotent adult progenitor cells are of donor origin after syngenetic BMT

Transplant Medicine - Reports add new data to Transplant Medicine research

Transplantation Medicine - Immune responses can be modulated in liver transplantation

Type 2 Diabetes - Glimepiride plus insulin therapy improved of glycemic control poorly controlled diabetes

Vasculitis - Mycophenolate mofetil is an option in relapsing or resistant ANCA small vessel vasculitis

Virology - Research in virology provides new insights

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