Sepsis
Melatonin may protect against mtNOS-mediated mitochondrial failure
Published in Blood Weekly, January 19th, 2006
"Mitochondrial nitric oxide synthase (mtNOS) produces nitric oxide (NO) to modulate mitochondrial respiration," researchers in Spain noted. "Besides a constitutive mtNOS isoform, it was recently suggested that mitochondria express an inducible isoform of the enzyme during sepsis."
"Thus, the mitochondrial respiratory inhibition and energy failure underlying skeletal muscle contractility failure observed in sepsis may reflect the high levels of NO produced by inducible mtNOS," argued G. Escames and colleagues at the University of Granada. "The fact that mtNOS...
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Source: Blood Weekly (2006-01-19)
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