Hemangioma
Transgenic rabbits model the features of Kasabach-Merritt syndrome
Published in Blood Weekly, January 26th, 2006
"Clinical studies have provided ample evidence that high (either systemic or local) levels of vascular endothelial growth factor (VEGF) are associated with several pathophysiological disorders, including hemangiomas. To investigate whether elevated VEGF expression could directly affect these disorders, we created a transgenic (Tg) rabbit model with increased hepatic expression of the human VEGF165 transgene under the control of the human alpha-antitrypsin promoter," researchers in Japan report.
"Tg rabbits exhibited marked hepatomegaly, with livers 2.5-fold heavier than...
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Source: Blood Weekly (2006-01-26)
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