B Cells

Interleukin-7 activates STAT5 and induces proliferation of human pro-B cells

Published in Blood Weekly, February 2nd, 2006

According to recent research from the United States, murine and human IL-7 activate STAT5 and induce proliferation of normal human pro-B cells.

"The role of IL-7 in lymphoid development and T cell homeostasis has been extensively documented. However, the role of IL-7 in human B cell development remains unclear," wrote S.E. Johnson and colleagues, University of Minnesota.

"We used a xenogeneic human cord blood stem cell/murine stromal cell culture to study the development of CD19+ B-lineage cells expressing the IL-7R. CD34+ cord blood stem cells were cultured on the MS-5 murine stromal cell line supplemented with human G-CSF and stem cell...

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Source: Blood Weekly (2006-02-02)

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