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Acute Myeloid Leukemia

FAB and WHO classification of acute myeloid leukemia discussed

Published in Blood Weekly, February 2nd, 2006

The French-American-British (FAB) and World Health Organization (WHO) classification of acute myeloid leukemia (AML) were discussed.

According to recent research from Germany, "In routine diagnostic procedures of AML, the FAB and WHO classifications both play a central role. Some morphologic subtypes are specifically associated to distinct cytogenetic and molecular aberrations; however, such close correlations do not exist for the majority of entities."

"We evaluated cytogenetics in 2,235 patients at diagnosis of AML with the FAB subtypes M0-2, M4, and M5-7. The cytogenetic patterns of these subtypes showed differences with respect to the clonal...

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