Blood Weekly
Susan Hasty, Publisher
Table of Contents . . . February 9th, 2006
Non-Subscriber - Summaries OnlyRelated Areas: Other Issues in Blood Weekly | Other Publications
Blood Safety - Transfused allogenic blood was reduced by 31% using autotransfusion replacement systems
Cell Therapy - Enhancer-specified GFP-based FACS purifies spinal motor neurons from embryonic stem cells
Stem Cell Transplantation - Transplanted ESC-derived neurons contribute to restoration of spiral ganglion neurons
Tissue Engineering - Biodegradable polymer composite grafts promote survival/differentiation of retinal SCs
Acute Myeloid Leukemia - PAF-R presence on surface of leukemic cells not detected by flow cytometry
Acute Respiratory Distress Syndrome - Study reveals new player in sepsis-associated condition
Angiography - CT angiography reported comparable with DS angiography for detecting and characterizing posterior aneurysms
Angiology - Reports advance knowledge in angiology research
Angiology - TRPV4 forms a Ca2+ signaling complex with ryanodine receptors
Apoptosis - Heat shock protein protects hippocampal progenitor cells from apoptosis
Arteriogenesis - Granulocyte-macrophage colony-stimulating factor is an arteriogenic factor
Atorvastatin - Study finds time of day of drug administration did not impact efficacy
Bioterrorism - Sarin levels below 0.4 LD50 did not alter operant performance in guinea pigs
Blood Transfusion - Raising hemoglobin levels may have a potential survival benefit in critically ill patients
Bone Marrow Metastases - Tc-99m-MIBI used to detect bone marrow metastases in childhood solid tumors
Breast Cancer - RBC count up, alkaline phosphatase level down in patients receiving both CMF and tamoxifen
Breast Cancer - Use of efaproxiral in brain metastases from breast cancer improved survival
Business & Finance - Biotech company reviews highlights, outlines 2005 milestones
Business & Finance - Vascular suturing devices maker issues update on completion of Technology Visions merger
Cancer Therapy - Novel benzopyridothiadiazepines identified as potential active antitumor agents
Cancer Therapy - Novel thermosensitive 5-fluorouracil-cyclotriphosphazene conjugates evaluated
Cancer Therapy - Pegfilgrastim administered to prevent neutropenia in pediatric cancer patients
Cardiology - Autoantibodies against oxLDL are linked to severe chest pain attacks in CHD patients
Cardiology - Glucose intolerance is linked to high thioredoxin levels, which is indicates CAD
Cardiopulmonary Bypass - Warm blood temperature improves efficacy of leukodepleting arterial line filter
Cardiovascular Research - Dialysis, pneumonia, poor heart function predict long-term ventilation weaning failure
Cervical Cancer - Intra-arterial chemotherapy with and without embolization compared in cervical cancer
Clinical Trials - Favorable interim phase 2b results for PAD treatment reported
Collaborations - Pharma companies collaborate to maximize development and commercialization of blood clot dissolver
Collaborations - Strategic alliance formed to identify therapeutic oxygen delivery, biosensor technologies
Complementary & Alternative Medicine - Review examines epidemiology of alternative therapy use by patients with cardiovascular disease
DNA Research - Impaired DNA replication within progenitor cell pools promotes leukemogenesis
Diabetes Therapy - Rosiglitazone effect is more favorable than nateglinide on diabetes rat lipid profile
Diabetic Nephropathy - DBA/2 genetics and Akita (Ins2+/C96Y) are better diabetic nephropathy models in mice
Diabetic Retinopathy - JDRF-funded diabetes researchers find molecular link between hyperglycemia and retinopathy
Diagnostics - Noninvasive flow cytometry method detects spermatogenetic defects
Diagnostics - Rapid diagnostic tests useful for assessing parasite burden at delivery
Disease Associations - Analysis of pathways linking sleep disorders to cardiovascular disease is needed
Disease Associations - Blood pressure control priority when choosing antihypertensive drugs for type 2 diabetics
Disease Associations - Withdrawal of bisphosphonates not recommended for necrosis of the jaws
Drug Development - European marketing application accepted for Ovine Hyaluronidase for vitreous hemorrhage
Dyslipidemia - Statins reduce C-reactive protein levels, independent of their effect on lipids or blood pressure
Emergency Medicine - Portable CPB/ECMO casualty management system performs well in animal tests
Finance - Blood substitute developer reports $6.3 million loss for second quarter
Finance - Vascular-focused medical devices company reports Q4 2005 net sales up 60%
Fitness & Wellness - CoQ10 levels were elevated in healthy men in response to 4 weeks of supplementation
Fitness & Wellness - Creatine supplementation reduced muscle inosine monophosphate during endurance exercise
Gaucher Disease - Recombinant glucocerebrosidase uptake was demonstrated in a Gaucher disease model
Gene Therapy - Sea urchin sns chromatin insulator characterized in erythroid cells
Geriatrics - Complications of lumbar surgery are similar across age groups
Glanzmann Thrombasthenia - Recombinant factor VII may be effective in Glanzmann thrombasthenia
Healthcare Access - Limited healthcare access impairs glycemic control in low socioeconomic status diabetics
Healthcare Coverage - HbA1c testing improved less in areas with more Medicaid patients or fewer physicians
Heart Bypass - Aspirin and clopidogrel taken up to 2 days prior increase postoperative blood loss
Hematology - Thrombopoietin fuels vascular endothelial cell growth factor assembly in hematopoietic stem cells
Hematopoietic Stem Cells - Study identifies molecule essential for proper localization of blood stem cells
Hemoptysis - Management and treatment of massive hemoptysis should be multidisciplinary
Hepatitis B Virus - Naive antibody phage library contains HBV neutralizing antibody fragments
Hepatitis B Virus - Pre-emptive lamivudine treatment is warranted in heart transplant patients with chronic hepatitis B
Hepatitis C Virus - High mortality rate is associated with HCV cirrhosis in liver retransplantation
Hodgkin Disease - Combined-modality therapy resulted in local control of Hodgkin Disease
Hodgkin Disease - Successful ambulatory treatment of Hodgkin disease in Iranian children reported
Hypertension - Guidelines proposed for hypertension management in overweight and obese patients
Hypertension - Irbesartan with hydrochlorothiazide reduced ambulatory BP more than losartan with hydrochlorothiazide
Hypertension - Proteinuria reduction should be considered when selecting hypertensive treatment
Inflammation - T-bet controls selectin ligand expression in Th1 cells
Information Technology - Nix Health Care System purchases SafeTrace Tx transfusion management system
Intracerebral Hemorrhage - Constraint-induced movement therapy is better than hypothermia alone after intracerebral hemorrhage
Iron Deficiency - Dialysis products manufacturer completes phase III trial of hemodialysis iron-delivery product
Leukemia - Abnormal phenotypic features typical of T-LGL leukemia may hold diagnostic value
Leukemia - Efficacy of chemotherapy compared to bone marrow transplantation in leukemia
Leukemia - Findings in leukemia provide new insights
Leukemia - Four consecutive trials for childhood acute myeloid leukemia reviewed
Leukemia - Multiple myelomas and myeloid leukemias were sensitive to proteasome inhibitor I
Leukemia - New findings in the area of leukemia described
Leukemia - Pediatric acute myeloid leukemia subtype-specific therapies needed
Leukemia - Pharmacodynamic properties of aminopterin in refractory acute leukemia studied
Leukemia - Quercetin and trichostatin A exhibited cytotoxic effects in human leukemia cells
Liver Transplant - Orthotopic liver transplantation improves outcome in HIV-positive patients
Lung Transplantation - Inhaled anti-rejection drug improves lung transplant patients' survival rates
MALT Lymphoma - Patients with mucosa-associated lymphoid tissue lymphoma treated by oxaliplatin
Mantle Cell Lymphoma - Hypersensitivity to mosquito bites might indicate mantle cell lymphoma
Marketing - Maker of vascular suturing devices reports on increased sales efforts and successes
Mechanical Ventilation - Dynamic CT adds promising functional information for respiratory treatment
Medical Devices - Biomaterials developer submits extraction catheter 510(k) application to U.S. FDA
Medical Devices - Heart rate response to exercise doesn't affect cardiac output or cerebral perfusion
Medical Devices - Molecular adsorbent recycling system shows promise for treatment
Medical Devices - NovaLung membrane oxygenator effective as extracorporeal lung assist device in calves
Medical Devices - Novel aortic valvo-pump design may reduce thrombosis risk
Medical Devices - Novel microfluidic device mixes crowded biological solutions in milliseconds
Medical Devices - Prototype axial flow VAD with magnetically levitated impeller shows promise
Medical Devices - Reliable automatic speed control system developed for rotary blood pumps
Mergers & Acquisitions - Acquisition of public minority stake in Micro Therapeutics, Inc. completed
Muscle Physiology - Guanine nucleotide exchange factor modulates muscle regeneration, myogenesis, and adipogenesis
Myelodysplastic Syndrome - International prognostic scoring system for myelodysplastic syndromes refined
Myeloma - Inhibition of bone resorption decreased myeloma and tumor progression
Myocardial Infarction - Implanted muscle stem cells aid the infarcted heart better than myoblasts
Neurology - Prehospital blood glucose data for suspected cerebrovascular accident patients unnecessary
Neuroscience - Blocking the central NMDA receptor may enhance analgesia induced by peripheral opioid mechanisms
Neuroscience - Grg6 and Groucho/TLE have antagonistic neurologic functions
Non-Hodgkin Lymphoma - Organochlorine chemicals in plasma related to risk of non-Hodgkin lymphoma
Obesity Pathogenesis - Older adults show a negative relationship between obesity and BP to cognitive function
Oncology - Histone deacetylase inhibitors arrest VEGF production and stop human mantle cell lymphoma
Oncology - Researchers report details of new studies and findings in the area of oncology
Ovarian Cancer - TTR, Hb, ApoAI, and TF, combined with CA125, may improve early detection of ovarian cancer
Pharmaceutical Research - Human recombinant erythropoietin does not prevent tumor growth or angiogenesis
Plasmodium Falciparum - P. falciparum resistance to chloroquine measured by monitoring prevalence of gene mutations
Prenatal Health - Relaxed standards for blood lead levels during pregnancy may impact children's intelligence
Prostate Cancer - Predictors of successful acquisition of prostate cancer tissue by BMBx assessed
Prostate Cancer - Prostate cancer stem cells identified
Proteomics - GADD proteins may help bacterial verotoxin 1 arrest cell proliferation
Proteomics - Researchers describe findings in proteomics studies
Renal Cell Cancer - Nephron-sparing surgery performed in grafted kidneys to treat renal cell cancer
Stem Cell Banking - Banked donor ESC number estimated to provide maximum practical benefit for HLA matching
Stem Cell Research - 5-Bromo-2'-deoxyuridine is selectively toxic to neuronal precursors
Stem Cell Research - Acellular porcine aortic valve matrix reseeded with human mesenchymal progenitor cells
Stem Cell Research - Cell cycle of hematopoietic stem cells regulated by the niche
Stem Cell Research - Distinct sets of cell cycle proteins regulate hematopoietic stem cells
Stem Cell Research - ESC lineage differentiation can be manipulated by the expression of GATA factors
Stem Cell Research - Embryonic stem cell differentiation induces progesterone receptor gene expression
Stem Cell Research - Endothelial progenitor and bone marrow cell transfer influences atherosclerotic plaque size
Stem Cell Research - Esg1 with Oct4 and Sox2 plays a conserved role in stem and germ cell pluripotent pathway
Stem Cell Research - JNK and p38 MAP kinase may play dual roles on cell survival and apoptosis
Stem Cell Research - Low dose erythropoietin is effective following stem cell tranplantation
Stem Cell Research - Lysophospholipid receptor signaling helps maintain stem cell pluripotentiality
Stem Cell Research - Mesenchymal stem cells differentiate into tenocytes by bone morphogenetic protein gene transfer
Stem Cell Research - Murine mesenchymal and embryonic stem cells express a similar Hox gene profile
Stem Cell Research - Pluripotent embryonic stem cells functionally express several specialized ion channels
Stem Cell Research - Stem cells identified within amniotic fluid
Stem Cell Research - Subpopulation of umbilical cord blood cells have potential to become neural cells
Stem Cell Transplantation - Higher pre-HSCT DC1 cell levels and total DCs associated with improved survival
Stroke - Potential treatment for intracerebral hemorrhage under study
Stroke - Studies add new findings to stroke body of knowledge
Surgical Technology - U.S. FDA approves investigational clinical trial of On-X Prosthetic Heart Valve
Surgical Technology - U.S. FDA grants clearance for the Resolution Endovascular System
Thalassemia - Ferriprox prevents iron-induced heart disease and reduces cardiac death risk in thalassemia
Thromboembolism - Pre-chemotherapy platelet counts predict a patient's risk for venous thromboembolism
Tissue Engineering - Interstitial cells from heart valves express various sarcomeric proteins
Tissue Engineering - Osteoblastic cells cultured in 3D microfluidic environment
Tissue Engineering - Sodium ascorbate improves cell proliferation on hyaluronan-based vascular constructs
Transplant Medicine - 493 People in upper Midwest said yes to organ and tissue donation in 2005, a 56% increase
Transplant Medicine - Findings in transplant medicine provide new insights
Transplant Medicine - New research in the area of transplant medicine detailed
Transplant Medicine - Pharma company returns transplantation product rights to Fresenius Biotech
Transplantation Biology - Prenatal inoculation with adult bone marrow produces acceptance of renal allografts
Vascular Medicine - Watching funny movies boosts blood flow to the heart
Virology - Researchers' work adds to virology body of knowledge
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