Hematology
High dose factor VIIa improves clot structure and stability
Published in Blood Weekly, February 16th, 2006
"Factor IX (FIX) deficiency results in hemophilia B and high dose recombinant activated factor VII (rFVlla) can decrease bleeding. Previously, we showed that FIX deficiency results in a reduced rate and peak of thrombin generation."
"We have now used plasma and an in vitro coagulation model to examine the effect of these changes in thrombin generation on fibrin clot structure and stability," wrote A.S. Wolberg and colleagues, University of North Carolina.
"Low FIX delayed the clot formation...
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Source: Blood Weekly (2006-02-16)
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