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Blood Weekly

Susan Hasty, Publisher

Table of Contents . . . February 23rd, 2006

Non-Subscriber - Summaries Only

Related Areas: Other Issues in Blood Weekly | Other Publications

Blood Safety - Flow cytometry used to test sterility of buffy coat-derived platelet concentrates

Blood Safety - South African program associated with decline in HIV-1 in blood donations

Cell Therapy - Whole-blood leukodepletion filters are a source of CD34+ progenitors for cell therapy

Cord Blood - Donor cell-derived acute leukemia occurred following umbilical cord blood transplantation

Tissue Engineering - Autologous chondrocyte implantation may be cost effective in the long term

Acute Myeloid Leukemia - Modified conventional protocol for childhood AML well tolerated

Acute Myeloid Leukemia - mTOR regulates cell survival after etoposide treatment in primary AML cells

Adverse Drug Reaction - Antimicrobial agents can cause drug interactions in children treated for cancer

Anticoagulation - Scientists discover "gatekeeper" protein in blood clotting

Antithrombosis - Adiponectin is an endogenous antithrombotic factor

Apoptosis - IL-15 and IL-15R synthesis are enhanced in leukocytes in systemic lupus erythematosus

Apoptosis - Studies add new findings to apoptosis body of knowledge

Blood Irradiation - Radiosensitivity to cobalt-60 gamma irradiation determined for T cells in blood bags

Blood Pressure - Blood pressure control is associated with genetic activity

Breast Cancer - MDM2 protein expression is a negative prognostic marker in breast carcinoma

Business Update - Cord blood company CEO discusses company business model

Business Update - Cord blood preservation company acquires assets of New York umbilical cord blood company

Cancer Therapy - Recombinant human nucleoside transporters compared in model expression systems

Cardiology - Review addresses management of the metabolic syndrome and cardiovascular health

Cardiovascular Research - Clopidogrel antithrombotic effects are more pronounced in CAD patients with P1(A2) allele

Cell Storage - Desiccated sperm storage viable alternative to conventional cryopreservation

Chronic Kidney Disease - Predialysis psychoeducational intervention improves CKD long-term survival

Chronic Lymphocytic Leukemia - Poor-risk CLL patients undergoing ASCT have significant graft-versus-leukemia effect

Clinical Trials - Hematologic malignancies responsive to bortezomib treatment

Clinical Trials - Phase 3 trial of sickle cell disease treatment on course after planned safety review

Cord Blood - Cell-therapy company expands cord blood banking into India

Cord Blood - IL-21 induces differentiation of naive and memory B cells into Ab-secreting plasma cells

Diabetes Complications - Autonomic dysfunction, insulin resistance and hypertension are linked to diabetes

Diabetes Complications - Increased hs-CRP levels and fibrinogen influence vascular event risk in diabetes mellitus

Diabetes Control - Exercise training prevents hyperglycemia in Zucker diabetic fatty rats

Diabetes Epidemiology - Female subjects have higher intramyocellular lipid compared with male counterparts

Diabetes Pathogenesis - Researchers publish new studies and findings in the area of diabetes pathogenesis

Diabetes Research - Vascular complications of diabetes rooted in faulty cells

Diabetes Therapy - Data advance knowledge in diabetes therapy research

Diabetes Therapy - Two-day VLED lowered fasting plasma glucose in obese type 2 diabetics on insulin therapy

Diet & Nutrition - Eicosapentaenoic acid supplementation benefits chronic hepatitis C patients

Diet & Nutrition - Low-dose vitamin C does not improve diabetic endothelial dysfunction and insulin resistance

Diet & Nutrition - Vitamin D compounds displayed anti-cancer effects in leukemia

Disease Associations - Cataracts among cancer survivors assessed

Disease Associations - Current knowledge regarding hormones and their roles in inflammation is reviewed

Disease Associations - Markers predict mortality in HIV-infected patients with end-stage liver disease

Drug Development - Borate's oxazaborolidine ring can be modified, while maintaining Ca2+-blocking activity

Endovascular Therapy - Drug-coated angioplasty balloon may be able to replace arterial stents

Environmental Health - Findings in environmental health provide new insights

Finance - Alliance with University of Mississippi wins NIH research grant

Finance - Blood processing systems maker reports 7.7% increase in revenue

Finance - Diagnostics company announces financial results for third quarter

Fitness & Wellness - Heart rate predicts dehydration risk in cyclists exercising in predisposing conditions

Fitness & Wellness - Physical fitness plays key role in blood lactate decrease during active recovery

Fitness & Wellness - Pulmonary artery pressure and blood flow evaluated as prognosticators of lung cancer resection

Gastric Cancer - Anemia predicted outcome of FU-based first-line chemotherapy in gastric cancer

Genetics & Genomics - -1438A/G polymorphism is related to cardiovascular and metabolic disorders

Genetics & Genomics - Gene expression profiling clarifies tissue response to systemic blood loss

Genetics & Genomics - gp130 expression in BM microenvironment makes an important contribution to hematopoiesis

Heart Failure - Anemia is predictor of mortality in patients hospitalized with congestive heart failure

Hematology - Heparin therapy leads to platelet activation and prolonged PFA-100 closure time

Hemodialysis - Vascular access monitoring provides valuable clinical data in hemodialysis patients

Hepatitis C Research - Hepatitis C shown to recur rapidly after liver transplant

Hepatitis C Virus - Polymorphism exists in nonalcoholic steatohepatitis and HCV-related liver steatosis

Hepatocellular Cancer - Downstaging of hepatocellular carcinoma prior to liver transplantation achieved

Hypertension - A single nucleotide polymorphism accounts for differences in response to imidapril

Hypertension - Hypertension can be caused by a loss of genome buffering capacity of Dahl salt-sensitive model

Hypertension - Researchers detail new studies and findings in the area of hypertension

Hypertension - U.S. Hispanics who self-identify as black suffer higher rates of hypertension

Immunopharmacology - Antiviral effect of EPS-1 on PBMC seems to be related to pattern of cytokines induced

Immunotherapy - Whole cell vaccines developed to clear residual tumor cells in acute myeloid leukemia

Information Technology - Hamilton Medical Center deploys Wireless CareCollect patient safety solution

Ischemia - Intestine protected from ischemia-reperfusion injury by intraluminal hyperoxygenated solution

Ischemia - Researchers' work adds to ischemia body of knowledge

Ischemia - Similar perfusion produces differential necrosis in mouse strains after ischemia

Kidney Disease - Critical assessment of uremia research is presented

Kidney Disease - Review examines vascular calcification in patients with chronic kidney disease

Leukemia - ERG overexpression predicts a worse outcome in acute myeloid leukemia

Leukemia - Increased CD19 positive lymphocyte count linked to higher risk of B-CLL disease progression

Leukemia - Multidrug resistance of leukemia cells is mediated through glycoprotein and Bcl-2 regulation

Leukemia - Prednisolone recommended for severe hepatic injury caused by imatinib mesylate

Leukemia - Recent findings in leukemia provide new insights

Leukemia - Shorter duration of standard-dose consolidation therapy used to treat leukemia

Leukemia - VPA and ATRA used to treat patients with poor-risk acute myeloid leukemia

Leukemia Vaccine - Neutrophil granule proteins act as targets of leukemia-specific immune responses

Liver Disease - Hyperinsulinemia predicts hepatic fat content in subjects with normal transaminase levels

Lung Cancer - Risk factors for anemia in patients with lung cancer identified

Marketing - Sales meeting and customer selling tools released for blood coagulation systems

Medical Devices - New device may boost world supply, quality of blood platelets

Medical Devices - New findings in the area of medical devices described

Medical Devices - Novel model improves analysis of fluid flow in membrane compartment

Medical Devices - Premier members save $56,000 in AngioJet Rheolytic Thrombectomy System purchases

Mental Health - Depression diagnosis linked to hospitalization in long-term hemodialysis patients

Multiple Myeloma - Data demonstrates anticancer activity of Quadramet in multiple myeloma

Multiple Myeloma - Five to seven plasma exchanges for acute renal failure does not significantly affect outcome

Muscle Wasting Disease - Myostatin inhibition validated as a therapeutic approach to muscle wasting diseases

Natural Products - Green coffee bean extract has mild antihypertensive effects

Neurogenesis - BMSCs promote neurogenesis of endogenous neural stem cells in the hippocampus

Neurogenesis - F-spondin promotes nerve precursor differentiation

Neurogenesis - NSCs may play significant roles in pathophysiology of alcohol-related disorders

Obesity Pathogenesis - Intima media thickness in childhood obesity is related to cardiovascular risk

Oncology - Hypoxia creates alternative circulatory mechanisms in Ewing sarcoma

Oncology - New data illuminates research in oncology

Orthopedics - Research aims to create bone structures from cord blood stem cells

Patents - U.S. patent issued on use of photoselective vaporization technology for treating BPH

Pediatric Fitness & Wellness - Graded relation found between cardiorespiratory fitness, fatness, and blood pressure in youth

Pediatrics - Phase II/III pediatric trial with Defibrotide to prevent veno-occlusive disease begins

Peritoneal Dialysis - Simultaneous catheter removal and reinsertion feasible in treatment of P. aeruginosa ESI

Pharmaceutical Research - Dipyridamole decreases protease-activated receptor, annexin-V binding on platelets

Physiology - Serum alkaline phosphatase activity is chromosomally regulated

Polycystic Kidney Disease - Treatment trials underway for treatment of polycystic kidney disease

Product Licensing - Transfusion management system licensed to Dameron Hospital

Professional Education - Cardiovascular group, imaging company establish cardiovascular CT education partnership

Quality of Life - WHOQOL-BREF(TW) valid for quality-of-life assessment in Taiwanese patients

Sickle Cell Disease - Ultrasound used to identify stroke risk in children with sickle cell disease

Spinal Cord Injury - Transplanted embryonic stem cell-derived neural stem cells effective in spinal cord injury

Statins - P-selectin is suggested as marker for beneficial action of statins

Stem Cell Research - Cells enriched in neural tissue-committed SC markers are mobilized into blood after stroke

Stem Cell Research - Corneal keratocytes retain neural crest progenitor cell properties

Stem Cell Research - Distinct stem cell populations regenerate follicle and interfollicular epidermis

Stem Cell Research - ESCs differentiate into hair follicle-like structures as well as glandular structures

Stem Cell Research - Solitary stem cells found in living bone marrow

Stem Cell Therapy - Role of the nervous system in regulating stem cells discovered

Stem Cell Transplantation - Maximum PAI-1 plasma antigen levels not exceeding 120 ng/mL excludes VOD after HSCT

Stem Cell Transplantation - Mobilized CD34+ stem cells expanded for clinical use in serum-free medium

Stem Cell Transplantation - Single-dose pegfilgrastim for CD34+ cell mobilization is feasible

Stroke - High serum hsCRP levels are independent risk factor for future ischemic stroke

Stroke - Mechanistic justification for trial of insulin infusion therapy is proposed

Stroke - Study identifies patients most at risk for secondary strokes

Surgical Technology - Laparoscopic extraperitoneal tunneling with omentopexy effective for catheter placement

Surgical Technology - Researchers' work adds to surgical technology body of knowledge

Surgical Technology - Sutureless system shown effective for connecting arteries in head and neck reconstruction

Thrombosis - Challenges with existing treatments for thrombosis in cancer patients analyzed

Tissue Engineering - Findings describe new data in tissue engineering research

Tissue Engineering - Hydroxyapatite scaffolds for bone tissue engineering made by 3D printing

Tissue Engineering - Low-level laser irradiation stimulates osteogenic MSC phenotype seeded on 3D biomatrix

Tissue Engineering - Modified collagen fleece supports human bladder smooth muscle cell transplantation

Tissue Engineering - Nano-structured chitosan enhances dermal fibroblast growth

Tissue Engineering - PLLA/PLGA blended scaffolds modified by type II collagen used for cartilage regeneration

Tissue Engineering - Preosteoblasts produce extracellular matrix within pores of composite scaffolds

Tissue Engineering - Soluble phosphate glass fibers developed for bone-ligament interface repair

Tissue Engineering - Tissue engineered nasal cartilage matches typical mechanics of native hyaline cartilage

Toxicology - Supra-normal protein C levels affect some markers of endotoxemia

Transfusion Medicine - LDL apheresis in patients with severe hypercholesterolemia may lower CV risk

Transfusion Medicine - SafeTrace Tx transfusion management system licensed to Dameron Hospital

Transplant Medicine - Anemia may not be associated with mortality and renal graft loss

Transplant Medicine - Dialysis does not affect medical evaluation completion rate for kidney transplant candidates

Transplant Medicine - HHV8 seroconversion in post-transplant KS linked to viral transmission by the graft

Transplant Medicine - Lymphopenia and diabetes transferred by bone marrow transplantation to syngeneic DR.lyp/lyp

Transplant Medicine - Male germ cell transplantation is an emerging technology in livestock production

Transplant Medicine - U.S. FDA grants clearance for preparation of a cell concentrate from bone marrow aspirate

Type 1 Diabetes - Autoreactive CD8 T cells are associated with beta cell destruction in type 1 diabetes

Type 2 Diabetes - Atorvastatin lowers plasma LDL cholesterol and CRP in type 2 diabetics

Wound Repair - Recombinant protein promotes angiogenesis to help chronic venous ulcers heal

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