Blood Weekly
Susan Hasty, Publisher
Table of Contents . . . March 2nd, 2006
Non-Subscriber - Summaries OnlyRelated Areas: Other Issues in Blood Weekly | Other Publications
Cardiovascular Research - Engineered heart tissue offers insights into irregular heartbeats
Stem Cell Transplantation - HSCT feasible in infants with acute lymphoblastic leukemia
Stem Cell Transplantation - High cure rate of isolated CNS relapse by ASCT in pediatric acute lymphoblastic leukemia
Tissue Engineering - Bioactive scaffold supports fibroblast growth for connective tissue regeneration
Tissue Engineering - Hepatocyte culture system developed
Acute Myeloid Leukemia - Impaired C/EBP alpha function contributes directly to AML development
Alopecia - Alopecia a frequent complication in women receiving tacrolimus after SPK transplantation
Angiology - PPARgamma regulates Ang II-stimulated phosphatidylinositol 3-kinase
Antibiotics - In vitro, in vivo studies support development of pharmacodynamic parameters to determine drug dose
Apoptosis - Arsenic trioxide is a novel human neutrophil pro-apoptotic agent
Apoptosis - Mechanism by which diosgenin induces apoptosis in COX-2 deficient K562 described
Apoptosis - Suppression of PKCalpha may contribute to hepatic apoptosis during sepsis
Arthroplasty - Serum IL-8 correlates with osteolysis after hip replacement
Arthroplasty - Wound compression superior to drainage for reducing blood loss after hip replacement
Bacteriology - Polyphenols protect cells from Porphyromonas gingivalis, may be useful for enamel diseases
Bacteriology - Studies report 2 million Americans carry drug-resistant Staph bacterium
Business & Finance - Maker of blood oxygen monitoring system files registration for public equity offering
Cancer Metastasis - Study shows tumors spread when blood vessel structural cell activity is limited
Cancer Therapy - Alemtuzumab induces caspase-independent cell death in lymphocytic leukemia cells
Cancer Therapy - High-dose therapy increased complete response rate in multiple myeloma patients
Cancer Therapy - Lenalidomide and thalidomide exhibit distinct pharmacological profiles
Cardiac Regeneration - Evidence supports use of mesenchymal stem cells for cardiac regeneration
Cardiology - Long Distance Corridor Walk provides valid estimate of peak VO2 in older adults
Cardiovascular Disease - Single bolus dalteparin may be alternative to unfractionated heparin during PCI
Central Nervous System - Glutamate receptor agonist may be an effective tool for investigating stress-related CNS disorders
Childhood Cancer - Long-term outcomes of adult survivors of childhood cancer reviewed
Chronic Peritoneal Dialysis - Increasing chronic peritoneal dialysis cycles has low impact on phosphate removal
Cirrhosis - A model accurately predicts severe fibrosis or cirrhosis in chronic hepatitis C
Clinical Trials - Blood cancer patients not directed by their specialists to clinical trials, survey shows
Clinical Trials - Enrollment opened in phase 2 trial of DNA vaccine against cytomegalovirus
Clinical Trials - Plans for phase 2 trial of anticancer agent in elderly poor-risk AML patients announced
Clinical Trials - Report announces the MICHELANGELO OASIS-5 trial evaluating fondaparinux
Clinical Trials - WAVE trial to determine if oral anticoagulation improves on antiplatelet therapy alone
Colorectal Cancer - Prognosis for colorectal metastases improved by major hepatectomy after portal vein embolization
Complementary & Alternative Medicine - Danish agency decides medical products with ciclosporin may be substituted with caution
Complementary & Alternative Medicine - Fermented soy milk intake lowered cholesterol and TG liver buildup under oxidative stress
Complementary & Alternative Medicine - Laserpitin lowers hepatic triglyceride content in stroke-prone spontaneously hypertensive rats
Cyclosporin - Cyclosporin monitoring improves therapy in early and late stages post-transplantation
Cytomegalovirus - Valcyte did not protect against CMV infection in liver transplant recipients
Diabetes Complications - Resveratrol, a polyphenolic phytoalexin, attenuates diabetic nephropathy in rats
Diabetes Research - Model for myocardial infarction and heart failure in db/db diabetic mouse is developed
Diabetes Therapy - Long-term treatment with novel GSK-3 inhibitor improves glucose homeostasis in ob/ob mice
Diabetes Therapy - New data illuminates research in diabetes therapy
Diabetes Therapy - Studies advance knowledge in diabetes therapy research
Diagnostics - Contrast-enhanced subharmonic imaging may have use in perfusion assessment
Diagnostics - Fibrotest accurately diagnoses HCV in hemodialysis and renal transplants
Dialysis - Hematopoietic response to recombinant erythropoietin is modulated in dialysis
Disease Associations - Natural killer cells are immunoselected that lack stress-inducible ULBP
Drug Development - Apoptosis induced by plant alkaloid sampangine in human HL-60 leukemia cells
Drug Development - Synthetic heparin could replace animal-derived anticoagulant
Drug Resistance - Routine screening for antiplatelet drug resistance should not yet be standard practice
Finance - Coagulation monitoring systems maker reports Q1 revenue up 112%
Finance - Healthcare, drug company reports GAAP net Q4 05 sales of $2.3 billion, up 6% from year ago
Finance - Maker of blood processing systems prices public offering of common stock at $4 per share
Finance - Somanetics reports record net revenues for FY 2005
Gastroenterology - Endoscopic therapy optimal for bleeding peptic ulcer with adherent clot
Gastrointestinal Bleeding - Endoscopic treatment can successfully manage bleeding from Dieulafoy's lesions
HIV/AIDS Infection - HIV-1 selectively infects a subset of nonmaturing BDCA1-positive dendritic cells in human blood
Hematology - Antiphospholipid antibodies can affect point-of-care INR test results
Hematology - Dipyridamole decreases protease-activated receptor and annexin-v binding on platelets
Hematology - Prolyl hydroxylase domain protein 2 is essential for hypoxia-inducible factor regulation
Hematology - Researchers' data advance hematology research
Hemodialysis - Citrate anticoagulation regimen effective in continuous veno-venous hemofiltration
Hemodialysis - Outcome of tunneled femoral dialysis catheter placement elucidated
Hepatitis A Virus - HAV from clotting factors implicated in infections among hemophiliacs
Hepatitis B Virus - CD58 expression is related to HBV infection severity and degree of liver damage
Hepatitis C Virus - Donor age impacts survival in HCV patients receiving liver transplantation
Hepatitis C Virus - Excess weight may protect against early fibrosis after liver transplantation
Hepatitis C Virus - Hepatitis B virus Ig-lamivudine combination protects liver allografts
Hepatitis C Virus - Nongenetic determinants operate in spontaneous clearance of HCV in hemophiliacs
Hodgkin Disease - Chemotherapy alone used to treat Hodgkin disease in Indian children
Hypertension - Hypertension-associated nucleotide polymorphism did not diminish treatment efficacy with irbesartan
Hypertension - Hyperuricemia associated with need for antihypertensive therapy
Ischemia - Intraluminal hyperoxygenated solution minimizes mitochondrial structural and functional changes
Leukemia - Combination of HDAC inhibitors and TRAIL used to treat leukemia
Leukemia - ETS-related gene overexpression predicts a worse outcome in acute myeloid leukemia
Leukemia - Extracellular KIT receptor mutants in leukemia respond to imatinib mesylate
Leukemia - HRQOL concerns over use of dexamethasone in pediatric leukemia addressed
Leukemia - Mutant nucleophosmin predicted favorable prognosis in acute myeloid leukemia
Leukemia - NS-187 proposed as novel agent for imatinib-resistant leukemia
Leukemia - New findings in leukemia described
Leukemia - Nucleophosmin gene mutations predicted favorable prognosis in leukemia
Leukemia - Reports add new data to leukemia research
Leukemia - Research add new data to leukemia body of knowledge
Leukemia - Researchers describe findings in leukemia studies
Leukemia - Studies advance knowledge in leukemia research
Limb Regeneration - Limb regeneration prospects in humans considered from salamander regeneration perspective
Liver Disease - Leptin is not linked to hepatic steatosis, aminotransferases, and serum lipids in children
Lymphangiogenesis - Embryonic stem cells have the capacity to become lymphatic endothelial cells
Lymphoma - Local tumor invasiveness was most important predictor of survival in lymphoma
Market Analysis - China to become a world leader in stem cell research, according report
Marketing - U.S. distribution rights for Medtronic anastomotic vascular surgery device acquired
Medical Devices - Novel microfluidic lab card facilitates rare cancer cell analysis
Myeloid Leukemia - Nucleophosmin mutations linked to favorable prognosis in acute myeloid leukemia
Myocardial Infarction - Granulocyte colony-stimulating factor augments cellular cardiomyoplasty in the injured heart
Natural Products - Curcumin and quercetin improve early outcomes in cadaveric kidney transplant recipients
Neoplastic Diseases - Intestinal transplantation used to treat intra-abdominal neoplastic disease
Neurogenesis - Neural differentiation in chemically defined medium dependent on endogenous FGF signaling
Neurology - Monocytes foster vascular repair following brain injury
Obesity Pathogenesis - -308A TNF-alpha gene variant is linked to 23% risk of developing obesity and related diseases
Obesity Pathogenesis - IMT in childhood obesity indicates higher cardiovascular disease and diabetes risk
Obesity Pathogenesis - PLA2 activation is linked to generation of placental lipid signals and fetal obesity
Oncology - Heat shock protein-90 inhibitors can control multiple myeloma
Ophthalmology - Homocysteine may present a risk for age-related macular degeneration
Ovarian Cancer - Suppression of natural killer cell response mediated by the ovarian tumor marker CA125
Personnel - Company focused on blood viscosity appoints Dr. Ralph E. Holsworth, Jr. to management team
Pharmacology - Mouse pneumonia model requires human epithelial penetration data for extrapolation to human dosing
Prognostics - Low molecular weight heparin may improve prognosis of cancer patients
Prostate Cancer - Ixabepilone was active in patients with hormone-refractory prostate cancer
Retinoblastoma - More aggressive bone marrow screening in retinoblastoma patients not recommended
Ricin Vaccines - Positive phase I results of RiVax vaccine announced
Sports Medicine - Extra carbohydrate or protein calories does not improve athlete performance after recovery
Stem Cell Research - FGF6 conditioning may expand immature cell pool by myoblast dedifferentiation
Stem Cell Research - Functional human embryonic stem cell-derived neurons develop in mouse brain
Stem Cell Research - Functional mammary gland generated from a single stem cell
Stem Cell Research - Spermatogonia stem cells and somatic environment in the testis are involved in the aging process
Stem Cell Research - Synovium-derived mesenchymal stem cells have greater chondrogenesis potential than bone marrow-derived mesenchymal stem cells
Stem Cell Research - Testicular side population cell subpopulation lacks Oct4 expression
Stem Cell Transplantation - HHV-6 infection associated with SCT from an allelic-mismatch donor and steroid therapy
Stem Cell Transplantation - IL-12 associated with reduced relapse without increased incidence of GVHD after AHSCT
Stem Cell Transplantation - Preemptive once-daily ganciclovir safe/effective for CMV viremia after ASCT
Stem Cell Transplantation - Researchers provide details of new studies and findings in the area of stem cell transplantation
Stem Cell Transplantation - Small synthetic cyclic heptapeptide enhances donor bone marrow engraftment
Stem Cell Transplantation - Study examined kinetics of dendritic and T-cell chimerism in stem cell recipients
Stem Cell Transplantation - Transplanted neural stem cells engraft into injured newborn brain
Stem Cell Transplantation - Varicella-zoster virus infection in pediatric post-HSCT may be preceded by transaminitis
Synovial Sarcomas - Role of adjuvant therapies to treat grossly-resected synovial sarcoma discussed
Thrombocytopenia - Recombinant factor VIIa can control bleeding caused by thrombocytopenia
Thrombosis - Higher levels of whole blood aggregation with anti-alpha(IIb)beta(3) suggest subacute thrombosis
Tissue Engineering - 3D scaffolds compared for osteogenic differentiation potential of dermal fibroblasts
Tissue Engineering - Bone chips are suitable for culturing high numbers of differentiated osteoblast-like cells
Tissue Engineering - Collagen composite hydrogels developed for vocal fold lamina propria restoration
Tissue Engineering - Dexamethasone-functionalized gels induce osteogenic encapsulated MSC differentiation
Tissue Engineering - Enzymatic biodegradable multilayered films developed for gene applications
Tissue Engineering - Hybrid scaffold/cell construct repairs high-load-bearing osteochondral defects
Tissue Engineering - Modified PLGA scaffolds increase osteoblast adhesion and proliferation
Tissue Engineering - Osteoblast-like cells cultured on scaffolds support bone regeneration
Tissue Engineering - Researchers' work adds to tissue engineering body of knowledge
Tissue Sterilization - Sterilization service selected by Community Tissue Services
Transplant Medicine - HBsAg seropositive status after renal transplantation decreases positive outcomes
Transplant Medicine - Rituximab therapy is effective for cryoglobulinemia in renal transplants
Transplant Medicine - Studies describe new findings in transplant medicine research
Transplant Medicine - Unrelated BMT is feasible for adult T-cell leukemia/lymphoma treatment
Type 1 Diabetes - Diabetic children have higher osteoprotegerin levels, which may be reduced bone mass marker
Type 1 Diabetes - Lipid peroxidation increases during postprandial phase with glucose and triglyceride changes
Type 2 Diabetes - Elevated visfatin plasma levels are found in type 2 diabetics
Type 2 Diabetes - Timing of Humalog Mix25 injections did not impact after meal glucose fluctuations in elderly
Veno-Occlusive Disease - Defibrotide shows success treating severe veno-occlusive disease
Wound Healing - Cytokine integration enhances the angiogenic potential of collagen matrices during wound repair
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