Leukemia
Chromosomal translocations associated with poor prognosis in leukemia
Published in Blood Weekly, March 9th, 2006
"In CLL, chromosomes usually evade detailed cytogenetic analyses because cells poorly respond to the traditionally used set of mitogens. We applied novel technologies, such as stimulation of CLL cells either with CD40 ligand or with a combination of CpG-oligodeoxynucleoticles and IL-2, to increase the frequency of metaphase spreads for detailed chromosome analysis in 96 patients with CLL," researchers in Germany reported.
"This approach revealed that translocations occurred in 33 of 96 (34%) of our patients with CLL. The presence of...
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Source: Blood Weekly (2006-03-09)
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