Published in Blood Weekly, March 9th, 2006
"CD8+ T cell-mediated alloreactivity is generally believed to involve recognition of the alpha 1/alpha 2 domains of donor-type class I MHC molecules as well as the peptides they bind," wrote M.B.A. Heemskerk and colleagues, Leiden University.
"Using the CTLp assay outcome as a parameter for the induction of alloreactivity, we have retrospectively surveyed 80 hematopoietic stem cell donor/patient pairs that feature a range of allelic differences at single HLA-A, -B, and -C loci in an attempt...
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