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Blood Weekly

Susan Hasty, Publisher

Table of Contents . . . March 16th, 2006

Non-Subscriber - Summaries Only

Related Areas: Other Issues in Blood Weekly | Other Publications

Adverse Drug Reaction - Human coagulation factor VIIa therapy is linked to thromboembolism after unlabeled uses

Blood Safety - Cerus obtains exclusive rights to INTERCEPT Blood System

Blood Transfusions - Blood transfusions may transmit occult hepatitis B virus to adults and children

Tissue Engineering - Cultured normal skin explants produced more uniform and expansive in vivo-like neoepidermis

Tissue Engineering - Tissue engineered cardiovascular patch fabricated for cardiovascular surgery

Adverse Drug Reaction - Osteonecrosis of the jaw related to pamidronate therapy

Adverse Drug Reactions - Anemia caused by amphotericin B treatment elucidated

Anemia - Patients with aplastic anemia have diminished bone marrow angiogenesis

Angiology - Hyperhomocysteinemia inhibits postinjury re-endothelialization in mice

Angiology - Ligand reports $2 million payment as Glaxo begins study of eltrombopag for adult with ITP

Apoptosis - Apolipoprotein displays dual effect of induced apoptosis

Apoptosis - PKC epsilon controls protection against TRAIL in erythroid progenitors

Apoptosis - PKC412 inhibits growth of neoplastic mast cells expressing KIT mutation D816V

Apoptosis - Studies add new findings to apoptosis body of knowledge

Bioimplants - Pegasus Biologics launches new product that fortifies and promotes tissue ingrowth

Cancer Gene Therapy - Suppressor of cytokine signaling inhibits multiple myeloma cell proliferation

Cancer Therapy - Minidose warfarin therapy deemed effective for preventing thrombotic events

Cancer Therapy - Protein level predicts who will develop deadly complication after bone marrow transplant

Cancer Therapy - Tumor cell detection in blood and bone marrow should not influence therapy

Cardiology - Laminin gene deficiency produces heart disease and capillary defects in mice

Cardiology - New findings in cardiology described

Cardiovascular Disease - Renal transplant recipients with altered glycemia show higher BMI and Hb1Ac

Cardiovascular Research - Stent system studies show positive results in small vessels

Chronic Hepatitis C - Pegylated interferon alpha-2b monotherapy for chronic HCV confers no advantage in hemodialysis

Clinical Trials - Dosing of anti-inflammatory drug for peripheral arterial disease in 2b trial on schedule

Clinical Trials - Significant trial results on antisense drug to reduce cholesterol in humans reported

Colorectal Cancer - Researchers detail new studies and findings in the area of colorectal cancer

Complementary & Alternative Medicine - Weight loss accompanied by green tea supplement did not improve blood parameters significantly

Cryoglobulinemia - Combined therapy is effective for asymptomatic mixed cryoglobulinemia

Cystic Fibrosis - Monitoring cystic fibrosis patients' arterial blood oxyhemoglobin recommended

Diabetes Pathogenesis - Co-stimulatory signal blockage prolongs the survival of islet xenografts

Diabetes Pathogenesis - Microalbuminuria regression was high in diabetics under glycemic and blood pressure control

Diabetes Pathogenesis - Studies add new findings to diabetes pathogenesis body of knowledge

Diabetes Therapy - Rapid angiogenesis sustains islet transplant survival in diabetes models

Diabetes Therapy - Researchers report details of new studies and findings in the area of diabetes therapy

Diabetic Nephropathy - Researchers' work adds to diabetic nephropathy body of knowledge

Diagnostics - Uveal melanoma tyrosinase PCR testing may have prognostic value

Down Syndrome & Acute Lymphoblastic Leukemia - Characteristics and outcome of children with Down syndrome and ALL reviewed

Drug Development - Kensey Nash receives CE Mark approval for embolic protection system in saphenous vein graft

Drug Development - U.S. FDA grants orphan drug status to monoclonal antibody for treating type 1 diabetes

Gene Research - Involvement of cyclin D2 in human cancer evidenced

Hemangiomas - Infantile hemangioma lacks lymphatic competence

Hematology - Angiogenesis cytokines accelerate endothelial-like cell differentiation

Hematology - Cytomegalovirus controls myeloid progenitor cells to facilitate dissemination

Hematology - Researchers' findings advance hematology research

Hematopoiesis - FGF-4 and HGF induce cord blood-derived mesenchymal stem cell differentiation into hepatocytes

Hematopoiesis - Loss of transcription factor GATA-1 contributes to hematopoiesis

Hematopoiesis - Tie2 is not essential for hematopoietic cell development

Hepatitis B Virus - Adefovir dipivoxil is promising in lamivudine-resistant chronic HBV infections

Hepatitis B Virus - Adefovir dipivoxil treatment is beneficial in post-liver transplant patients

Hepatitis B Virus - Hepatitis B core antibodies are frequently detected in heart transplant recipients

Hepatitis C Virus - Cryoglobulinemia is prevalent in kidney transplant recipients

Hepatitis C Virus - Hepatitis C virus recurrence predicted in liver transplant patients

Hepatitis C Virus - Interferon and ribavirin are promising for recurrent hepatitis C after liver transplantation

Hepatitis C Virus - Interferon with ribavirin lessens recurrence of chronic HCV in transplant patients

Hepatocyte Transplantation - Small hepatocytes can repopulate the liver as if they were hepatic stem cells

Hyperglycemia & Hepatitis C - Hyperglycemia in those with hepatitis C displays an unconventional diabetic phenotype

Hypertension - New data illuminates research in hypertension

Hypertension - New series of renin inhibitors for hypertension reaches late-stage preclinical profiling

Ischemia - Modulation of PGE2 receptors may protect against neuronal injury induced by focal ischemia

Ischemic Stroke - Ischemic stroke study clinical data points to promising drug delivery treatments

Kidney Transplantation - Post-transplant diabetes mellitus is associated with high tacrolimus concentration-dose ratios

Leukemia - Aberrant methylation of multiple genes in acute lymphoblastic leukemia revealed

Leukemia - Berbamine proposed as novel bcr/abl inhibitor with potent anti-leukemia activity

Leukemia - CD10- pre-B acute lymphoblastic leukemia identified as a high-risk subtype of adult ALL

Leukemia - Chronic lymphocytic leukemia CD38 and NOS2 expression linked to IL-4 levels

Leukemia - Data advance knowledge in leukemia research

Leukemia - Elderly patients' attitude toward remission induction influenced survival

Leukemia - Findings advance knowledge in leukemia research

Leukemia - Lonafarnib used to treat select patients with chronic myelogenous leukemia refractory to imatinib

Leukemia - Quality of life assessed in children with leukemia after central venous catheter placement

Leukemia - Recent studies add new data to leukemia research

Leukemia - Reports describe recent advances in leukemia research

Leukemia - Researchers' data advance leukemia research

Leukemia - Valproic acid deemed clinically useful in low-risk myelodysplastic syndrome

Liver Transplantation - Acute graft-versus-host disease can be diagnosed by high levels of donor T-cell chimerism

Liver Transplantation - Liver organ donation could get a boost from non-heart beating donors

Malaria Immunogenicity - Parasite Ag-specific CD4 cells generated in utero in placental P. falciparum infection

Melanoma - Laser Doppler perfusion images cannot distinguish tumor angiogenesis from reactive hyperemia

Myeloma - Prognostic impact of cytogenetic aberrations in patients with myeloma detailed

Neurogenesis - Neurogenesis occurs in the adult caudate nucleus

Neuroscience - Schwann cells differentially promote peripheral nerve regeneration

Neurosurgery - Adding furosemide to hypertonic saline decreases brain water content without increasing osmolality

Non-Hodgkin Lymphoma - Findings advance knowledge in Non-Hodgkin lymphoma research

Obesity Epidemiology - Obesity and weight gain is common following renal transplantation

Obstructive Sleep Apnea - Obstructive sleep apnea syndrome may account for unexplained creatine phosphokinase elevation

Occult Cancer & Critical Leg Ischemia - Occult cancer associated with critical leg ischemia

Oncology - Cell growth factor spawns tumor angiogenesis in cancer models

Pain Management - Morphine, topical anesthesia effective in treating pain in newborn infants

Pancreatic Cancer - Weekly cisplatin and gemcitabine used to treat patients with pancreatic cancer

Parkinson Disease - Expanded neural precursor cell grafts survive long term in Parkinson disease model

Pediatric Cardiology - In neonates with transposed great arteries, balloon atrial septostomy is a risk factor for preop stroke

Pediatric Stroke - Pediatric stroke diagnosis often delayed by unsuspecting hospital caregivers, study shows

Peripheral Vascular Disease - Autologous bone marrow stem cells improve chronic limb ischemia

Personnel - Cord blood stem cell preservation company names Timothy McGrath to board

Prostate Cancer - Prostate UCB injection delays onset of prostate cancer and improves survival

Stem Cell Mobilization - Chronic heart failure may be attenuated by blood stem cell mobilization

Stem Cell Research - Cultured mesenchymal stem cells transdifferentiate into Schwann cell-like myelinating cells

Stem Cell Research - Embryonic stem cells differentiate into cardiomyocytes with functional characteristics

Stem Cell Research - Four embryonic stem cell lines established in Denmark

Stem Cell Research - GATA-1 affects erythrocyte proliferation and differentiation by different mechanisms

Stem Cell Research - M-FISH sensitive and accurate method for comprehensive ESC karyotype analysis

Stem Cell Research - Rad temporally regulated in myogenic progenitor cells during skeletal muscle regeneration

Stem Cell Transplantation - Comparable results in ALL patients after related and unrelated SCT

Stem Cell Transplantation - Hematopoietic stem cells do not engraft with absolute efficiencies

Stem Cell Transplantation - Ischemic neuronal damage reduced by neural stem cell grafts

Stem Cell Transplantation - Neural SCT in stomach rescues gastric function in neuronal nitric oxide synthase-deficiency

Stem Cell Transplantation - Transplanted hepatic stem-like cells differentiate into functional hepatocytes

Stroke - Recent studies add new data to stroke research

Stroke - Researchers describe findings in stroke studies

Thrombosis - Combined clinical pretest probability and D-dimer test used to detect thrombosis in cancer patients

Tissue Engineering - Bioactive glass scaffolds optimized for bone tissue engineering

Tissue Engineering - Biological disc repair evolving with knowledge of disc aging events

Tissue Engineering - Penile girth enhanced with autologous ex vivo tissue engineering scaffolds

Tissue Engineering - Researchers' findings advance tissue engineering research

Tissue Engineering - Superior extracellular matrix formation in nanofiber over membrane-type scaffolds

Transplant Medicine - Animal study shows ETA-RA has protective effect on microcirculation after liver transplant

Transplant Medicine - Cyclosporine suppresses hepatic stellate cell growth and collagen production

Transplant Medicine - New research in the area of transplant medicine detailed

Transplant Medicine - Norman Shumway, heart transplantation pioneer, dies at age 83

Transplant Medicine - Researchers detail new studies and findings in the area of transplant medicine

Transplant Medicine - Use of anti-cytomegalovirus IgG is warranted in lung transplantation

Transplantation Biology - Prognosis after liver transplantation modeled

Type 1 Diabetes - Type 1 diabetes cure may be found in islet transplants

Venous Thromboembolism - Arixtra shown to reduce patients' risk of venous thromboembolism by 46.7%

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