Diabetes Pathogenesis
Co-stimulatory signal blockage prolongs the survival of islet xenografts
Published in Blood Weekly, March 16th, 2006
"CTLA4Ig, a recombinant fusion protein composed of the extracellular domain of human CTLA4 and the constant region of human IgG1, inhibits the interaction of CD28/B7 pathway by binding the B7 molecule. OX40Ig, a recombinant fusion protein composed of the extracellular domain of human OX40 and the constant region of human IgG1, abrogates the interaction of OX40/OX40L pathway by binding the OX40L on APCs."
"So...
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Source: Blood Weekly (2006-03-16)
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