Ischemia may resolve after alpha 4 integrin disruption

According to a study from the United States, "The cell surface receptor alpha 4 integrin plays a critical role in the homing, engraftment, and maintenance of hematopoietic progenitor cells (HPCs) in the bone marrow (BM). Down-regulation or functional blockade of alpha 4 integrin or its ligand vascular cell adhesion molecule-1 mobilizes long-term HPCs."

"We investigated the role of alpha 4 integrin in the mobilization and homing of BM endothelial progenitor cells (EPCs). EPCs with endothelial colony-forming activity in the BM are exclusively alpha 4 integrin-expressing cells. In vivo, a single...

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