Cancer Immunotherapy
Kinase insert domain-containing receptor draws cytotoxic cells to tumor vessels
Published in Blood Weekly, April 6th, 2006
"Antigen-specific cancer immunotherapy directed toward tumor-nourishing angiogenic blood vessels holds the promise of high efficacy, low toxicity, and ease of application. To evaluate whether the human angiogenic KDR can serve as a target for cellular immunotherapy, 19 peptide sequences with HLA-A*0201 motifs were selected by computer-based algorithms," scientists writing in the journal Blood report.
"Five peptides (KDR82-90, KDR288-297, KDR766-774, KDR1093-1101, KDR1035-1044) stimulated specific cytotoxic T lymphocytes (CTLs) from peripheral-blood...
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Source: Blood Weekly (2006-04-06)
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