Published in Blood Weekly, April 6th, 2006
"The roles of aberrant expression of constitutively active ALK chimeric proteins in the pathogenesis of anaplastic large-cell lymphoma (ALCL) have been well defined; nevertheless, the notion that ALK is a molecular target for the therapeutic modulation of ALK+ ALCL has not been validated thus far.
"Select fused pyrrolocar-bazole (FP)-derived small molecules with ALK inhibitory activity were used as pharmacologic tools to evaluate whether...
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