Cancer Therapy

Anaplastic lymphoma kinase activity is essential for lymphoma cells

Published in Blood Weekly, April 6th, 2006

According to recent research from the United States published in the journal Blood, anaplastic lymphoma kinase activity is essential for the proliferation and survival of anaplastic large-cell lymphoma cells.

"The roles of aberrant expression of constitutively active ALK chimeric proteins in the pathogenesis of anaplastic large-cell lymphoma (ALCL) have been well defined; nevertheless, the notion that ALK is a molecular target for the therapeutic modulation of ALK+ ALCL has not been validated thus far.

"Select fused pyrrolocar-bazole (FP)-derived small molecules with ALK inhibitory activity were used as pharmacologic tools to evaluate whether...

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Source: Blood Weekly (2006-04-06)

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