Lipid Research

Downregulation of LDL receptor expression by IL-1 beta alters cardiac lipid metabolism during sepsis

Published in Blood Weekly, April 6th, 2006

Interleukin-1 beta is suggested as a principle mediator of changes in cardiac lipid and energy metabolism during sepsis through the downregulation of myocardial very low-density lipoprotein receptor expression.

Investigators writing in the journal Cardiovascular Research report, "Sepsis accompanies myocardial dysfunction and dynamic alterations of cardiac metabolism. We have recently demonstrated that the very low-density lipoprotein receptor (VLDL-R), which is abundantly expressed in the heart, plays a key role in energy metabolism of the fasting heart. However, little is known about the function and regulation of the VLDL-R during sepsis."

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Source: Blood Weekly (2006-04-06)

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