Stem Cell Research
Human hepatocytes repopulate the liver in a chimeric mouse model
Published in Blood Weekly, April 6th, 2006
"A small animal model harboring a functional human liver cell xenograft would be a useful tool to study human liver cell biology, drug metabolism, and infections with hepatotropic viruses.
"Here we describe the repopulation, organization, and function of human hepatocytes in a mouse recipient and the infections with hepatitis B virus (HBV) and hepatitis C virus (HCV) of the transplanted cells," wrote J.D. Perkins and colleagues, University of Washington. "Homozygous urokinase plasminogen activator (uPA)-SCID mice underwent...
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Source: Blood Weekly (2006-04-06)
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