Hematopoiesis
Peroxide-sensitive regulatory mechanisms play important role in controlling hematopoiesis
Published in Blood Weekly, April 27th, 2006
According to recent research from the United States, "Culturing mouse bone marrow in the presence of catalase dramatically alters hematopoiesis. Granulocyte output is initially increased 4- to 5-fold. This increase is transient and granulocyte production declines as immature (Sca-1+/LIN-) cells accumulate.
"One third of these immature cells have a phenotype (Sca-1+/c-Kit+) characteristic of hematopoietic stem cells. At 2 to 3 weeks there are greater than 200-fold more Sca-1+/c-Kit+/LIN-cells in treated cultures than in controls. This population contains...
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Source: Blood Weekly (2006-04-27)
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