Stem Cell Research
Cell selection based on ALDH activity and CD133 expression isolates long-term reconstituting HSCs
Published in Blood Weekly, April 27th, 2006
"The development of novel cell-based therapies requires understanding of distinct human hematopoietic stem and progenitor cell populations. We recently isolated reconstituting hematopoietic stem cells (HSCs) by lineage depletion and purification based on high aldehyde dehydrogenase activity (ALDH(hi)Lin-cells).
"Here, we further dissected the ALDH(hi)-Lin-population by selection for CD133, a surface molecule expressed on progenitors from hematopoietic, endothelial, and neural lineages," scientists in the United...
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Source: Blood Weekly (2006-04-27)
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