Allografts
Vascularized allograft rejection is induced by platelet-derived or soluble CD154
Published in Blood Weekly, May 4th, 2006
"CD154 is a cell surface molecule expressed on activated T cells that binds to CD40, an activating molecule on APCs. Its blockade has been shown to prevent allograft rejection, presumably by interrupting interactions between T cells and APCs," wrote H. Xu and colleagues, U.S. National Institute of Diabetes & Digestive Kidney Diseases.
They continued, "It is known that activated human platelets express and shed CD 154 and can induce APC activation and other immune processes in vitro. Here we show that platelet-derived CD154...
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Source: Blood Weekly (2006-05-04)
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