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Stem Cell Research

Aspirin abates endothelial progenitor cell proliferation and vasculogenic capacity

Published in Blood Weekly, May 11th, 2006

Aspirin abates endothelial progenitor cell (EPC) proliferation and vasculogenic capacity.

Scientists in the People's Republic of China conducted a study "to investigate whether aspirin has an influence on EPC. Total mononuclear cells (MNC) were isolated from peripheral blood by Ficoll density gradient centrifugation, then cells were plated on fibronectin-coated culture dishes. After 7 d of culture, attached cells were stimulated with aspirin (to achieve final concentrations of 1, 2, 5, and 10 mmol/L) for 3, 6, 12, and 24 h."

"EPC were characterized as adherent cells that were double positive for 1,1-dioctadecyl-3,3,3,3-tetramethylindocarbocyanine low...

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