Progenitor Cells

Neural progenitor cell differentiation is mediated by neurogenin

Published in Blood Weekly, May 18th, 2006

According to a recent study from the United States, neural progenitor cell differentiation is mediated by neurogenin 1 (Ngn1).

"Proneuronal basic helix-loop-helix (bHLH) transcription factor, Ngn1, regulates neuronal differentiation during development of the cerebral cortex. Akt mediates proneuronal bHLH protein function to promote neuronal differentiation," wrote L. Wang and colleagues, Henry Ford Hospital.

They continued, "Here, we show that recombinant human erythropoietin (rhEPO) significantly increased Akt activity and Ngn1 mRNA levels in neural progenitor cells derived from the subventricular zone (SVZ) of adult rat, which was coincident with...

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Source: Blood Weekly (2006-05-18)

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