Cancer Therapy
Human leukemic cells are affected by a synthetic triterpenoid
Published in Blood Weekly, May 25th, 2006
According to recently published research from the United States, human leukemic cells are affected by a synthetic triterpenoid, C-28 methyl ester of 2-cyano-3,12-dioxoolean-1,9-dien-28-oic acid (CDDO-Me), which inhibits I kappa B alpha, kinase and enhances apoptosis induced by TNF and chemotherapeutic agents through down-regulation of expression of nuclear factor kappa B-regulated gene products.
"CDDO-Me, a synthetic triterpenoid based on naturally occurring ursolic and oleanolic acids, induces apoptosis in tumor cells, induces differentiation, and inhibits inflammatory response through a poorly understood mechanism.
"Because the nuclear...
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Source: Blood Weekly (2006-05-25)
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