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Hepatitis C Virus

Hepatitis C virus RNA-dependent RNA polymerase inhibitors identified

Published in Blood Weekly, May 25th, 2006

Recent research from the United States has reported on the identification of novel inhibitors of hepatitis C virus (HCV) RNA-dependent RNA polymerase (RdRp).

"HCV is a major cause of chronic hepatitis, liver cirrhosis, and hepatocellular carcinoma worldwide, and is the main cause of adult liver transplants in developed nations. We have identified a class of novel and specific inhibitors of HCV NS5B RdRp activity in vitro," wrote G. Lee and colleagues, Amgen Inc.

"Characterization of two such inhibitors, COMPOUND1 (5-(4-chlorophenylmethylene)-3-(benzenesulfonylamino)4-oxxo-2-thionothiazolidine) and COMPOUND2...

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