Leukemia

Researchers' findings from Germany, the United States and Taiwan advance leukemia research

Published in Blood Weekly, May 25th, 2006

Investigators in Germany, the United States and Taiwan have published new leukemia data.

Study 1: Valproic acid (VPA) was deemed clinically useful in low-risk myelodysplastic syndrome (MDS).

According to a study from Germany, "VPA inhibits historic deacetylase activity and induces differentiation of acute myeloid leukemia (AML) blasts in vitro. We observed clinical responses to VIA in patients with MDS and AML."

"Here, we report follow-up data on 75 patients. Of these, 66 were started on VPA monotherapy, with later addition of all-trans retinoic acid (ATRA) in patients who did not respond or relapsed. Nine patients were treated...

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Source: Blood Weekly (2006-05-25)

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