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Bone Regeneration

PBMSCs may be a new source of circulating osteogenic stem cells for bone regeneration

Published in Blood Weekly, June 15th, 2006

Peripheral blood-derived mesenchymal stem cells enhance bone regeneration in ulna critical-sized bone defect.

"Mesenchymal stem cells (MSCs) were demonstrated to exist within peripheral blood (PB) of several mammalian species including human, guinea pig, mice, rat, and rabbit. Whether or not the PB derived MSCs (PBMSCs) could enhance the regeneration of large bone defects have not been reported.

"In this study, rabbit MSCs were obtained from mononuclear cells (MNCs) cultures of both the PB and bone marrow (BM) origin," researchers in North Ireland report.

According to the authors, "The number of PBMSCs was relatively lower, with...

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