Hematopoiesis
Lack of alpha 4 integrin expression in stem cells restricts competitive function and self-renewal
Published in Blood Weekly, June 15th, 2006
According to a recently published study from the United States, "Alpha4 integrin or VLA4 (CD49d/CD29) is a multitask molecule with wide expression within and outside the hematopoietic system.
"Because targeted ablation of alpha 4 integrin leads to embryonic lethality, to study its effects on adult hematopoiesis, we used animals with conditional excision of alpha 4 integrin (alpha 4(Delta/Delta)) in hematopoietic cells."
"In such animals," wrote G.V. Priestley and colleagues at the University of Washington, "we previously documented...
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Source: Blood Weekly (2006-06-15)
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