Stem Cell Transplantation
HSCT-related graft failure in thalassemia reduced by unrelated donor selection
Published in Blood Weekly, June 15th, 2006
According to a recently published study from Italy, "The success of allogeneic hematopoietic stem cell transplantation (HSCT) from matched unrelated donors (UDs) for beta-thalassemia may be hampered by the occurrence of graft rejection.
"Here, we show that the rate of this complication can be reduced by selecting 5-loci HLA-matched donors without nonpermissive mismatches at HLA-DPB1, defined according to an algorithm previously described and based on principles of...
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Source: Blood Weekly (2006-06-15)
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