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Stem Cell Research

Boundary cap neural crest SCs differentiate into Schwann cells under defined culture conditions

Published in Blood Weekly, June 15th, 2006

Boundary cap neural crest stem cells differentiate into adult Schwann cells under defined culture conditions.

According to recent research published in the journal Experimental Neurology, "Boundary cap cells can generate neurons as well as peripheral glia during embryonic development, and, recently, the boundary cap was shown to contain multipotent stem cells. The ability of stem cells to generate mature functional glial phenotypes has not been addressed."

"In this study, we have explored the competence of boundary neural crest stem cells (bNCSCs) to differentiate into mature functional Schwann cells (SCs) in vitro and in vivo. bNCSCs failed...

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