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Transplants

New data from the United States, Denmark and Japan lluminates research in transplants

Published in Blood Weekly, June 22nd, 2006

Data on transplants are outlined in reports from the United States, Denmark and Japan.

Study 1: According to recently published research from the United States, corneal allograft rejection differentially involves CD8+ and CD8- T lymphocytes.

"We examined the role of perforin and FasL in corneal allograft rejection mediated by CD8+ and CD8- T cells. BALB/c corneas were transplanted orthotopically into vascularized, 'high-risk' graft beds in C57BL/6 mice, perforin knockout mice and FasL-defective gld/gld mice," wrote J.Y. Niederkorn and colleagues, University of Texas, Dallas.

They explained, "CD8+ and CD8- T cells were collected...

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