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Diabetes Pathogenesis

High betaine-homocysteine S-methyltransferase expression may lower homocysteine in diabetes

Published in Blood Weekly, June 22nd, 2006

Decreased plasma homocysteine in diabetes models could be brought about by increased betaine-homocysteine S-methyltransferase expression.

According to a study from Canada, "Elevation of plasma homocysteine levels has been recognized as an independent risk factor for the development of cardiovascular disease, a major complication of diabetes. Plasma homocysteine reflects a balance between its synthesis via S-adenosyl-L-methionine-dependent methylation reactions and its removal through the transmethylation and the transsulfuration pathways."

"Betaine-homocysteine methyltransferase (BHMT, EC 2.1.1.5) is one of the enzymes involved in the remethylation...

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