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Tissue Engineering

Tissue-engineered bone grafts can be transferred to lesions lacking adequate blood supply

Published in Blood Weekly, June 22nd, 2006

Vascularized tissue-engineered bone grafts can be transferred to lesions that lack adequate blood supply.

According to recent research from Japan, "Vascularized bone grafting has become a useful method for treatment of large bone defects and infected nonunions that lack adequate blood supply. This method has disadvantages, however, such as donor-site complications.

"To overcome these disadvantages, the authors developed a new method for creating vascularized tissue-engineered bone grafts in an experimental model. Fisher rat bone marrow mesenchymal stem cells were cultured for 2 weeks in fully opened, interconnected, porous hydroxyapatite...

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