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Blood Weekly

Susan Hasty, Publisher

Table of Contents . . . June 29th, 2006

Non-Subscriber - Summaries Only

Related Areas: Other Issues in Blood Weekly | Other Publications

Blood Banking - Economies of scale in blood banking determined

Blood Transfusion - High-throughput method for blood donor antigen profiling has been developed

Blood Transfusion - HLA antibody screening is recommended in patients with RBC alloantibodies before transfusion

Tissue Engineering - Composite scaffolds developed for vascular tissue engineering

Vascular Graft - Vascular graft healing dependent on fluid dynamics in artery-graft-artery construct

Acute Radiation Sickness - ImmuneRegen and ORNL announce initial results from Radilex testing

Amyloidosis - Hereditary systemic amyloidosis amyloidogenic transthyretin can be selectively suppressed

Angiology - Angiogenic growth proceeds without marrow cell incorporation after VEGF stimulation

Angiology - Neovascular response to ischemia is specific to cell type

Apoptosis - CREB prevented apoptosis triggered by Bax

Apoptosis - Erythropoietin is unlikely to disrupt effectiveness of cancer chemotherapeutic drugs

Artificial Liver Support - Cell-free artificial liver support trial guidelines minimize systematic errors

Artificial Liver Support - Extracorporeal liver support device is a therapeutic option in artificial liver support

Atherosclerosis - Cerebrovascular ischemic events are not commonly due to atherosclerotic aortic emboli

Bacteriology - Lethality of Gram-positive bacterial hemolysins depends on cytolytic activity

Bioartificial Liver - Optimal bioartificial liver system still under development

Blood Banking - A human T-lymphotropic virus (HTLV) antibody-testing program is evaluated

Blood Safety - Nucleic acid amplification test results are integrated into hepatitis C testing algorithms

Blood Vessel Regeneration - CD11(low) cells are a good source of cells for blood vessel regeneration

Bone Marrow Transplantation - Survival improved for children requiring intensive care after bone marrow transplant

Business Update - Clearant recaps new direct sales strategy announced at investor presentation

Business Update - Clinical data on Pharmion's marketed and pipeline products presented at ASCO annual meeting

Business Update - Cord Blood America CEO plans to be extremely aggressive in acquisitions, asset purchases

Business Update - Daxor announces South Carolina hospital purchases Blood Volume Analyzer BVA-100

Cardiac Regeneration - Integrative studies are needed to achieve full potential of cardiac regeneration

Cardiology - A tiny centrifugal blood pump is developed for use in pediatric patients

Cardiology - A ventricular assist device with full magnetic suspension of the rotor has been developed

Cardiology - Axial flow blood pump design may provide better pumping efficiency

Cardiology - Blood pump-associated hemolysis is a result of surface-caused shear stress

Cardiology - Centrifugal blood pump components are not the source of released particles

Cardiology - Endotoxemic inflammatory pathways are not influenced by dobutamine

Cardiology - Left ventricular assist device-associated implantable electronic unit is developed

Cardiology - LVAD axial flow prototype with optimization of the magnetic suspension is designed

Cardiology - Neurally mediated syncope therapy can be based on diagnostic implantable loop recorders

Cardiology - Pacing and ICD leads successfully extracted using an excimer laser-assisted technique

Cardiology - Prepump administration of urinary trypsin inhibitor attenuates interleukin increases

Cardiology - Sedation prior to coronary interventions may reduce myocardial damage

Cell Therapy - Local platelet-rich plasma administration may stimulate intervertebral disc repair

Cell Therapy - Postinfarct cytokine therapy regenerates cardiac tissue and improves LV function

Clinical Trials - Clot permeability, fibrinolysis are enhanced by statins, fenofibrate, and quinapril

Colon Cancer - Colonoscopy negative results more likely in individuals taking anticoagulant medications

Cord Blood - ViaCell, Children's Hospital Oakland Research Institute expand sibling cord blood donor program

Critical Care Medicine - Intensive care infants should receive extracorporeal oxygenation with conversion to a VAD

Diabetes Complications - Diabetes impairs the ability of transplanted cells to stimulate angiogenesis in ischemic limbs

Diagnostics - CD38 expression correlates with cell mutation status in chronic lymphocytic leukemia

Disease Associations - Second primary cancer risk in patients who have had transplants was not substantiated

Embryogenesis - Gonadotropins affect Oct-4 gene expression during mouse oocyte growth

Embryonic Stem Cell Research - Embryonic stem cells are sensitive to cytotoxic effects of the solvent dimethyl sulfoxide

Embryonic Stem Cell Research - Human embryonic stem cells propagated on immortalized drug-resistant cell line

Facilities - Enpath Medical plans facility consolidation

Finance - Endologix announces $20.0 million direct equity placement

Finance - Gentium raises $22.1 million in private offering to support pipeline development

Food Allergies - Case studies suggest direct relationship between tacrolimus, development of food allergy

Genetics & Genomics - Atypical myeloproliferative disease involves plasminogen activator inhibitor

Genetics & Genomics - Patients can have monoclonal gammopathies and hereditary amyloid proteins

Graft-versus-Host Disease - CCL27/CTACK-CCR10 interaction recruits CD4 cells to skin in graft-versus-host disease

Graft-versus-Host Disease - Response favorable for extracorporeal photopheresis in children with GVHD

HIV/AIDS - Chembio participates in United Nations' High-Level Meetings on AIDS

Heart Failure - Cardiac resynchronization therapy effects in chronic heart failure are discussed

Heart Transplantation - Artificial heart malfunction may be detected with an automatic diagnosis system

Heart Transplantation - Blood pump leakage flow rate associated with surface roughness and gap clearance

Heart Transplantation - Centrifugal rotary blood pump can detect left ventricular function

Hematology - ADAMTS-13 plasma level reveals antigen absence in thrombotic thrombocytopenic purpura

Hematology - Bivalirudin anticoagulation is monitored by Thrombelastograph ecarin clotting time assay

Hematology - Cardiopulmonary bypass is associated with degradation of tissue factor pathway inhibitor

Hematology - Platelet angiostatin propels angiogenesis with the help of urokinase plasminogen activator

Hematology - Sm22.6 antigen inhibits human thrombin

Hematology - Thrombosis risk increase with age is linked to hemostatic and inflammatory variables

Hematopoietic Tumors - Hematopoietic tumor treatment should involve developing therapies that target HAUSP

Hemophilia - Developing strategies for worldwide hemophilia treatment are discussed

Hepatitis C Virus - HCV genotypic diversity does not influence assay sensitivity

Herpes Simplex Virus Type 2 Vaccine - Recombinant vesicular stomatitis virus vector immunogenic against HSV-2

Immunoregulation - Siglec-H functions as an endocytic receptor on dendritic cell precursors

Infection Management - Infection management is challenging in cancer and stem cell transplant patients

Infectious Diseases - Bacterial endotoxin inhibits the enzymatic activity of human thrombin

Intravenous Immune Globulin - Current usage of intravenous immune globulin is subject of review

Ischemia - Hypothermic protection against pulmonary ischemia-reperfusion injury depends on endothelial NOS

Leukemia - Leukemia cells harboring t(15;17) can have PU.1 expression restored by all-trans retinoic acid

Leukemia - Leukemia cells might be selectively inhibited by phenylhexyl isothiocyanate

Leukemia - Leukemia treated with bortezomib experienced enhanced cytotoxic effects of combination chemotherapy

Liver Failure - HepaLife achieves major cell biology objective in artificial liver device research

Lymphoma Complications - Autologous hematopoietic cell transplant mortality is not linked to BMI in lymphoma patients

Market Analysis - Increasing interest in cholesterol-lowering treatment drives phytosterol sales

Market Analysis - Report evaluates market opportunities stem cells present in biotechnology sector

Medical Devices - IRIS enters into contract with Mayo Foundation for iQ200 Systems

Medical Devices - U.S. Food and Drug Administration clears Boston Scientific system for removing clots from arteries

Mental Health - Telephone counseling improves quality of life for lung transplant hopefuls

Molecular Diagnostics - RAPD technique genotypes coagulase-negative staphylococci strains within 4 hours

Myeloma - Multiple myeloma treatment by osteoblast suppression described

Myocardial Infarction - Hearts with myocardial infarction may improve upon interleukin-8 stimulation of progenitor cells

Neonatology - Newborn screening can cause unnecessary parental stress

Obesity Complications - Obesity is a possible cause for reactive leukocytosis

Oncology - Myelofibrosis with myeloid metaplasia responds to thalidomide in some patients

Organ Donation - Organ and tissue donor brochure addresses concerns among religious community

Patents - U.S. patent office rejects PharmaStem's claims

Percutaneous Coronary Intervention - Data indicate a prospective randomized trial of high-dose tirofiban vs. abciximab is warranted

Peripheral Nerve Regeneration - Peripheral nerve regeneration presents a significant clinical challenge

Personnel - Dr. Gabor Rubanyi of Berlex Biosciences joins Cardium as chief scientific officer

Polycythemia Vera - HSC mutation in polycythemia vera predisposes toward erythroid differentiation

RNA Interference - Short hairpin RNAs delivered into mouse embryonic stem cells

Renal Transplantation - Plasma-cell enrichment indicates more adverse outcome in renal transplantation

Sepsis - Dopamine is capable of modulating cellular immune functions in a murine model of sepsis

Sepsis - Sepsis-related hormone resistance impairs cytokine and growth hormone signaling

Septicemia - Sedimentation characteristics of leukocytes can predict bacteremia

Sickle Cell Anemia - Equity and quality in sickle cell disease treatment are the focus of review

Sickle Cell Disease - Icagen initiates pediatric clinical development of ICA-17043 for sickle cell disease

Spermatogenesis - Irradiated testes efficiently support spermatogenesis derived from donor germ cells

Stem Cell Research - 473HD-chondroitinsulfate epitope is involved in neural precursor cell proliferation

Stem Cell Research - AAM3100 mobilizes hematopoietic stem cells with long-term repopulating capacity

Stem Cell Research - Alpha-smooth muscle actin-positive cells play role in cartilage development and maintenance

Stem Cell Research - Bone marrow-derived cells fuse with normal and transformed intestinal stem cells

Stem Cell Research - Hematopoietic progenitor cell line displays differentiation potential

Stem Cell Transplantation - Allogeneic hematopoietic stem cell transplantation favors altered hypothalamic dopaminergic tone

Thalassemia Therapy - Deferasirox and deferiprone are useful for iron overload in thalassemia major

Tissue Donations - Professionals must ensure human tissues obtained from proper sources, says Science Care

Tissue Engineering - Accelerated biomimetic coprecipitation yields a bonelike apatite/collagen composite coating

Tissue Engineering - Cell-seeding into 3D porous scaffolds enhanced by use of magnetite nanoparticles

Tissue Engineering - Collagen-based scaffold reinforced by chitin fibers designed for bone tissue engineering

Tissue Engineering - Decellularization efficiency depends on tissue origin and method used

Tissue Engineering - Flat collagen and elastin scaffolds for tissue engineering prepared by freeze-drying

Tissue Engineering - Osteoblast differentiation and matrix mineralization regulated by transglutaminase activity

Tissue Engineering - Tissue engineering scaffolds mimic soft tissue mechanical anisotropy

Transplant Medicine - Fetal lung tissue might be an option for adult lung regeneration

Transplant Medicine - Rituximab is effective and safe in B-PTLD

Transplant Medicine - Urinary IP-10 expression after kidney transplant may be correlated with graft function

Waldenstrom Macroglobulinemia - BLyS inhibition has potential therapeutic potential in Waldenstrom macroglobulinemia

Angiology - Reports from Poland, Japan and the United States describe recent advances in angiology research

Apoptosis - Findings from the People's Republic of China, United Kingdom and Greece in apoptosis provide new insights

Biomedical Engineering - Researchers from Finland and the United States report details of new studies and findings in the area of biomedical engineering

Biomedical Engineering - Studies from France, the People's Republic of China and Japan describe new findings in biomedical engineering research

Blood Banks - Researchers from the United States detail new studies and findings in the area of blood banks

Cancer Treatment - Researchers' findings from the Czech Republic, Australia and United States advance cancer treatment research

Cardiology - Research from the United States add new data to cardiology body of knowledge

Cell Biology - Data from France and the United States advance knowledge in cell biology research

Cell Biology - Researchers from Sweden, Japan and Israel provide details of new studies and findings in the area of cell biology

Cell Biology - Researchers' findings from Spain, the United States and the United Kingdom advance cell biology research

Cell Biology - Studies from India, the South Korea and the United Kingdom advance knowledge in cell biology research

Cord Blood - Findings from the United States in cord blood provide new insights

Diabetes - New data from the United States and Turkey lluminates research in diabetes

Diabetes - Research from the United States and France add new data to diabetes body of knowledge

Diabetes - Researchers from the United States and Germany detail new studies and findings in the area of diabetes

Genetics - Research from the United States add new data to genetics body of knowledge

Genetics - Researchers from the People's Republic of China and Australia report details of new studies and findings in the area of genetics

HIV/AIDS - Reports from Brazil, Netherlands and France add new data to HIV/AIDS research

Heart Attack - New findings from the United States, United Kingdom and Greece in the area of heart attack described

Hematology - Researchers from Finland, Sweden and Germany describe findings in hematology studies

Hepatitis C Virus - Research from Israel and the United States in hepatitis C virus provides new insights

Hepatocellular Carcinoma - Recent findings from the United States, Netherlands and People's Republic of China illuminate research in hepatocellular carcinoma

Imaging - Researchers from the United Kingdom, Germany and United States report details of new studies and findings in the area of imaging

Leukemia - Findings from Norway, the United States and Germany describe new data in leukemia research

Leukemia - New findings in leukemia described from Spain, Switzerland and the United States

Leukemia - Reports from Italy and the United States describe recent advances in leukemia research

Leukemia - Researchers' data from the United States and Japan advance leukemia research

Lymphoma - New findings in lymphoma described from the United States and United Kingdom

Melanoma - Research from the United States and the Netherlands in melanoma provides new insights

Neurology - Reports from the United States and Israel describe recent advances in neurology research

Obesity - Research from Australia, France and the United States add new data to obesity body of knowledge

Obesity - Researchers from the United States and Australia describe findings in obesity studies

Transplants - Findings from Brazil, Turkey and Germany in transplants provide new insights

Transplants - Recent findings from the United States illuminate research in transplants

Transplants - Reports from Germany and the United States describe recent advances in transplants research

Transplants - Researchers from the United States, Japan and Belgium report details of new studies and findings in the area of transplants

Transplants - Researchers' work from Turkey, the the Netherlands and Denmark adds to transplants body of knowledge

Virology - Researchers from the United States report recent findings in virology

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