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Transplant Medicine

Fetal lung tissue might be an option for adult lung regeneration

Published in Blood Weekly, June 29th, 2006

Some fetal rat lung fragments thrive when implanted into adult rat lung parenchyma.

"The capability of regeneration of lung tissues in adults is limited after chronic destruction. Bone marrow-derived stem cells, retinoic acid, growth factors, and other approaches have been attempted to promote or facilitate this process. We hypothesized that fetal lung tissues, with great potential for growth and differentiation, could be used for lung regeneration," investigators in Japan report.

"Day 17 fetal lung tissue fragments at the pseudoglandular stage of lung development from Lewis rats were implanted into adult Lewis rat lungs. For group 1, fetal lung...

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