Diagnostics

CD38 expression correlates with cell mutation status in chronic lymphocytic leukemia

Published in Blood Weekly, June 29th, 2006

According to a study from the Netherlands, CD38 expression correlates with cell mutation status in chronic lymphocytic leukemia.

"Increased CD38 expression by leukemic cells has been suggested as an adverse prognostic factor in B-CLL. Several approaches have been proposed to quantify its level of expression by flow cytometry," wrote J.G. Boonstra and colleagues, University of Rotterdam.

They continued, "We compared the use of (i) the percentage of CD38 positive cells, (ii) CD38 antibodies bound per cell (ABC), and (iii) a semi-quantitative method based on the shape of the CD38 histogram, within a cohort of 78 B-CLL patients."

"A...

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Source: Blood Weekly (2006-06-29)

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