Vascular Graft

Vascular graft healing dependent on fluid dynamics in artery-graft-artery construct

Published in Blood Weekly, June 29th, 2006

The healing of tissue engineered vascular grafts is dependent on fluid dynamics in the artery-graft-artery construct.

"A polyester (PET) reinforced fibrin-FN-VEGF-TGF beta vascular graft, formed by a four-step preclotting technique of a porous PET arterial graft, shows the overlapping inflammation, proliferation, and remodeling steps of normal wound healing when implanted in the descending thoracic aorta (DTA) position in the dog, forming a surface layer of endothelial cells.

"While the DTA grafts readily healed (i.e., endothelialized), similar grafts implanted in the carotid-femoral artery position did not fully heal," researchers in the United...

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Source: Blood Weekly (2006-06-29)

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