Thrombotic Thrombocytopenic Purpura

Rituximab may decrease treatment failure rates in thrombotic thrombocytopenic purpura

Published in Blood Weekly, July 6th, 2006

Rituximab may decrease treatment failure rates in patients with thrombotic thrombocytopenic purpura.

According to a recently published study from the United States, "The rationale for immunosuppressive therapy of thrombotic thrombocytopenic purpura (TTP) was established by observations that TTP may be caused by autoantibodies to ADAMTS13.

"Patients with high-titer autoantibodies to ADAMTS13 may have a higher mortality, and survivors may require prolonged plasma exchange therapy in spite of adjunctive glucocorticoid treatment. More intensive immunosuppressive therapy with rituximab may provide benefit for many of these patients."

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Source: Blood Weekly (2006-07-06)

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