Transplant Medicine

Preservation injury may target subcellular endoplasmic reticulum early

Published in Blood Weekly, July 6th, 2006

The endoplasmic reticulum may be an early subcellular target of preservation injury.

Researchers in Germany report, "The endoplasmic reticulum (ER) represents a subcellular target reactive to various cytosolic impairments. The involvement of ER-stress in organ preservation was investigated, comparing machine preservation, cold storage (CS) and a novel concept of only temporary perfusion after procurement."

"Rat livers were retrieved 30 min after cardiac arrest and preserved for 18 h by CS, oxygenated machine perfusion for 18 h (18 h MP) or for 2 h with subsequent CS for 16 h (2 h MP + 16 h CS)," wrote T. Minor and colleagues at the University Clinic...

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Source: Blood Weekly (2006-07-06)

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