Neuroscience

Focal cerebral ischemic damage can be salvaged by hemoglobin polymer transfusion

Published in Blood Weekly, July 6th, 2006

According to a recent study from the United States, focal cerebral ischemic damage can be salvaged by transfusion of high O₂ -affinity recombinant hemoglobin polymers.

"Cellfree hemoglobin solutions with high oxygen affinity might be beneficial for selectively delivering oxygen to ischemic tissue. A recombinant hybrid hemoglobin molecule was designed using the human alpha-subunit and the bovine beta-subunit, with placement of surface cysteines to permit disulfide bond polymerization of the tetramers," wrote M. Nemoto and colleagues, Johns Hopkins University Hospital.

"The resulting protein generated from an Escherichia coli...

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Source: Blood Weekly (2006-07-06)

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