Breast Cancer
Breast cancer angiogenesis is modulated by protease-activated receptor-2 control of MAPK pathways
Published in Blood Weekly, July 13th, 2006
"PAR2 is a G-protein coupled receptor that is cleaved and activated by serine proteases including the coagulation protease factor VIIa (FVIIa). There is evidence that PAR2 function contributes to angiogenesis, but the mechanisms involved are poorly defined," scientists in the United States report.
"Here we show that PAR2 activation in human breast cancer cells leads to the upregulation of vascular endothelial growth factor (VEGF). Activation of PAR2 with agonist peptide (AP), trypsin or FVIIa, results in a...
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Source: Blood Weekly (2006-07-13)
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